TLDR Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.
The study characterized canine epidermal neural crest stem cells (cEPI-NCSC) from various dog breeds, demonstrating their multipotency and self-renewal abilities. These cells, derived from the hair follicle bulge, expressed neural crest and pluripotency genes and could generate all major neural crest derivatives. The research highlighted the potential of cEPI-NCSC as candidates for cell-based therapies in canine spinal cord injury (SCI), especially in chondrodystrophic dogs, due to their close relationship with spinal cord stem cells. This work laid the foundation for developing new treatments for SCI in dogs and provided a promising large animal model for human SCI research.
36 citations,
April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.
45 citations,
December 2009 in “Veterinary dermatology” The book is recommended for its new scientific information and balanced treatment options for hair loss in domestic animals.
4 citations,
January 2009 in “Wiley-Blackwell eBooks” The book explains causes, diagnosis, and treatments for hair loss in pets.
417 citations,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
44 citations,
January 2015 in “Development” Human Schwann cells can be quickly made from hair follicle stem cells for nerve repair.
31 citations,
August 2015 in “Stem Cells Translational Medicine” Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
November 2023 in “Research Square (Research Square)” NIR-II imaging effectively tracked stem cells that helped repair facial nerve defects in rats.
4 citations,
February 2020 in “Cell & tissue research/Cell and tissue research” Hair follicle stem cells might help treat traumatic brain injury.
138 citations,
June 2019 in “Stem Cells and Development” Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.
