Multimodal Imaging of Hair Follicle Bulge-Derived Stem Cells in a Mouse Model of Traumatic Brain Injury

    February 2020 in “ Cell & tissue research/Cell and tissue research ”
    Timo Schomann, Juvita D. Iljas, Ivo Que, Yuedan Li, Ernst Suidgeest, Luis J. Cruz, Johan H. M. Frijns, Alan Chan, Clemens Löwik, Margriet A. Huisman, Laura Mezzanotte
    Image of study
    TLDR Hair follicle stem cells might help treat traumatic brain injury.
    This study investigated the potential of adult hair follicle bulge-derived stem cells (HFBSCs) for treating traumatic brain injury (TBI) in a mouse model. HFBSCs, which can differentiate into neurons and are relatively immune-privileged, were transplanted into the cortical region of nude mice 2 days post-injury. Using multimodal imaging techniques, the researchers tracked the survival and localization of these cells. The results showed that HFBSCs survived for 58 days post-transplantation, differentiated towards a neuronal lineage, and expressed markers such as nestin and neurofilament protein. These findings suggest that HFBSCs could be a viable option for cell-based therapy in TBI.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Clearing the air on how non-surgical treatments really work

       18 upvotes 5 years ago
      Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

      community RU58841 alone vs. with Fin / Dut

      in Finasteride/Dutasteride  11 upvotes 1 year ago
      RU58841 combined with finasteride or dutasteride is more effective than RU58841 alone for hair loss. Users suggest combining these with minoxidil and microneedling for better results.

    Similar Research

    5 / 1000+ results