Multimodal Imaging of Hair Follicle Bulge-Derived Stem Cells in a Mouse Model of Traumatic Brain Injury

    February 2020 in “ Cell & tissue research/Cell and tissue research ”
    Timo Schomann, Juvita D. Iljas, Ivo Que, Yuedan Li, Ernst Suidgeest, Luis J. Cruz, Johan H. M. Frijns, Alan Chan, Clemens Löwik, Margriet A. Huisman, Laura Mezzanotte
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    TLDR Hair follicle stem cells might help treat traumatic brain injury.
    This study investigated the potential of adult hair follicle bulge-derived stem cells (HFBSCs) for treating traumatic brain injury (TBI) in a mouse model. HFBSCs, which can differentiate into neurons and are relatively immune-privileged, were transplanted into the cortical region of nude mice 2 days post-injury. Using multimodal imaging techniques, the researchers tracked the survival and localization of these cells. The results showed that HFBSCs survived for 58 days post-transplantation, differentiated towards a neuronal lineage, and expressed markers such as nestin and neurofilament protein. These findings suggest that HFBSCs could be a viable option for cell-based therapy in TBI.
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