Hair Follicle Stem Cells: In Vitro and In Vivo Neural Differentiation

The document discussed the potential of hair follicle stem cells (HFSCs) to differentiate into neural cells both in vitro and in vivo, highlighting their accessibility and ability to proliferate. HFSCs were shown to express neural markers and integrate into neural tissues, suggesting their use in treating neurodegenerative diseases and injuries. Studies demonstrated HFSCs' ability to form neurons, astrocytes, and oligodendrocytes, and their application in models of spinal cord injury and Alzheimer's disease showed promising results. HFSCs promoted axonal regeneration, neuronal replacement, and functional recovery without forming tumors, and facilitated peripheral nerve repair. Despite these promising results, challenges such as limited in vivo differentiation and the need for further studies to ensure functional integration remained.