TLDR Hair follicle stem cells can become different cell types and may help treat neurodegenerative disorders.
The document discussed the potential of hair follicle stem cells (HFSCs) to differentiate into neural cells both in vitro and in vivo, highlighting their accessibility and ability to proliferate. HFSCs were shown to express neural markers and integrate into neural tissues, suggesting their use in treating neurodegenerative diseases and injuries. Studies demonstrated HFSCs' ability to form neurons, astrocytes, and oligodendrocytes, and their application in models of spinal cord injury and Alzheimer's disease showed promising results. HFSCs promoted axonal regeneration, neuronal replacement, and functional recovery without forming tumors, and facilitated peripheral nerve repair. Despite these promising results, challenges such as limited in vivo differentiation and the need for further studies to ensure functional integration remained.
18 citations,
October 2014 in “In vitro cellular & developmental biology. Animal” Hair follicle stem cells can become neural cells using different methods, with varying efficiency.
7 citations,
September 2013 in “Tissue engineering. Part A” Hair follicle stem cells can become motor neurons and reduce muscle loss after nerve injury.
550 citations,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
92 citations,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.
949 citations,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
130 citations,
January 1994 in “Differentiation” Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.
12 citations,
October 2021 in “Cells” Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
2 citations,
August 2022 in “BMC veterinary research” Hair follicle stem cells from Arbas Cashmere goats can become fat, nerve, and liver cells.
August 2023 in “Military Medical Research” Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.
1 citations,
June 2023 in “Journal of Cellular and Molecular Medicine” The new method using gene-modified stem cells and a 3D printed scaffold improved skin repair in mice.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
