Uncomplicated Differentiation of Stem Cells Into Bipolar Neurons and Myelinating Glia

September 2008 in “ Biochemical and Biophysical Research Communications ”

Ragad El Seady, Margriet A. Huisman, Clemens W.G.M. Löwik, Johan H. M. Frijns

epidermal neural crest stem cells EPI-NCSCs hair follicles neurons myelinating glial cells nestin TUJ1 Krox-20 OSP bipolar neurons multipotent stem cells autologous stem cell therapy neural regeneration stem cells hair follicle stem cells nerve cells glial cells stem cell therapy

TLDR Hair follicles can be used to easily create neurons and glial cells for potential nerve repair.

The study investigated the differentiation of epidermal neural crest stem cells (EPI-NCSCs) from hair follicles into neurons and myelinating glial cells. EPI-NCSCs showed high nestin positivity and successfully differentiated into neurons (70% TUJ1-positive) and glial cells (30% Krox-20 positive, 20% OSP-positive). The research demonstrated a simple method for generating bipolar neurons and myelinating glial cells, highlighting hair follicles as a valuable source of multipotent stem cells. This offered promising potential for autologous stem cell therapy in neurological disorders, suggesting significant possibilities for neural regeneration in both peripheral and central nervous systems. Further studies were recommended to fully explore their therapeutic potential.

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