TLDR Human epidermal neural crest stem cells could be used for therapies, drug discovery, and disease modeling.
The review discussed the potential of human epidermal neural crest stem cells (hEPI-NCSC) for use in translational medicine. These multipotent somatic stem cells, derived from the embryonic neural crest, are found in the bulge of hair follicles and can be easily isolated and expanded ex vivo. hEPI-NCSC do not form tumors in vivo and can differentiate into various clinically relevant cell types. These properties make them promising candidates for cell-based therapies, drug discovery, and disease modeling.
17 citations,
January 2014 in “Stem Cells Translational Medicine” Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.
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March 2011 in “Stem Cell Reviews and Reports” Human epidermal neural crest stem cells can become bone and skin pigment cells, making them useful for therapies.
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January 2015 in “Development” Human Schwann cells can be quickly made from hair follicle stem cells for nerve repair.
91 citations,
March 2011 in “Stem Cell Reviews and Reports” Human epidermal neural crest stem cells can become bone and skin pigment cells, making them useful for therapies.
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January 2014 in “Stem Cells Translational Medicine” Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.
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