TLDR Human Schwann cells can be quickly made from hair follicle stem cells for nerve repair.
The study demonstrated that human epidermal neural crest stem cells (hEPI-NCSCs) could be efficiently differentiated into Schwann cells without genetic manipulation. By manipulating specific signaling pathways, the researchers achieved Schwann cell marker expression in nearly all cells by day 4, with full maturation by 2 weeks. These Schwann cells expressed essential neurotrophic and angiogenic factors, interacted functionally with rodent axons, and showed potential for nerve repair and regeneration. The findings suggested that hEPI-NCSCs could be a valuable resource for developing therapies for nerve damage and related conditions, highlighting their promise in regenerative medicine.
13 citations,
September 2014 in “Birth defects research” Human epidermal neural crest stem cells could be used for therapies, drug discovery, and disease modeling.
17 citations,
January 2014 in “Stem Cells Translational Medicine” Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.
11 citations,
February 2019 in “Stem cells international” Skin-derived stem cells grow faster and are easier to obtain than hair follicle stem cells, but both can become various cell types.
3 citations,
May 2013 in “International journal of molecular sciences” Epidermal stem cells show promise for treating orthopedic injuries and diseases.
31 citations,
August 2015 in “Stem Cells Translational Medicine” Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
17 citations,
January 2014 in “Stem Cells Translational Medicine” Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.
August 2023 in “Stem cell reviews and reports”
