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GlossarySchwann cells

specialized cells that insulate and support peripheral nerve fibers

Schwann cells are specialized cells in the peripheral nervous system that wrap around nerve fibers to form the myelin sheath, which insulates the nerves and speeds up the transmission of electrical signals. They play a crucial role in nerve regeneration and repair by providing support and nutrients to neurons.

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research Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves

319 citations , November 2005 in “Proceedings of the National Academy of Sciences”

Hair follicle stem cells can help repair damaged nerves.

research Human Epidermal Neural Crest Stem Cells as a Source of Schwann Cells

44 citations , January 2015 in “Development”

Human Schwann cells can be quickly made from hair follicle stem cells for nerve repair.

The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

research The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

5 citations , January 2023 in “Cell proliferation”

Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.

research PIK3CA Gain-Of-Function Mutation In Schwann Cells Leads To Severe Neuropathy And Aerobic Glycolysis Through A Non-Cell Autonomous Effect

June 2025 in “Proceedings of the National Academy of Sciences”

A PIK3CA mutation in Schwann cells causes severe nerve damage and increased glycolysis, but early treatment can help.

research Keratin Biomaterials Activate Schwann Cells via Integrin-Mediated Signaling and Promote Regeneration of Large Peripheral Nerve Defects in a Rabbit Model

April 2009 in “The FASEB Journal”

Keratin biomaterials from human hair help nerve regeneration by activating Schwann cells.

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