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Glossary Disease Modeling

scientific method to simulate and predict disease behavior

Disease Modeling is a scientific method used to understand how diseases develop and spread within populations. It involves creating mathematical or computational simulations to predict the course of a disease, evaluate potential interventions, and inform public health strategies. This approach is crucial for planning responses to outbreaks and understanding the dynamics of diseases like COVID-19, influenza, or even conditions like alopecia.

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Research

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research Human epidermal neural crest stem cells as candidates for cell-based therapies, disease modeling, and drug discovery

13 citations , September 2014 in “Birth defects research”

This review discusses human epidermal neural crest stem cells (hEPI-NCSC) as candidates for cell-based therapies and drug discovery but reports no new experimental results.

research Skin Organoids for Disease Modelling, Drug Screening and Regenerative Medicine: Recent Advances and Future Perspectives

January 2026 in “Wound Repair and Regeneration”

This review summarizes the latest progress and challenges in skin organoid research, emphasizing advancements in organoid construction, applications in disease modeling, and factors affecting tissue maturation, while noting barriers such as vascularization and neural integration that hinder clinical translation.

research 779 Multicellular skin organoids as a unique modeling platform for skin physiology, injury, and disease

July 2024 in “Journal of Investigative Dermatology”

The new skin organoid system effectively mimics human skin for studying its functions, injuries, and diseases.

research Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications

33 citations , December 2015 in “International Journal of Molecular Sciences”

This review discusses recent research on melanocyte stem cells and explores the differences between mouse and human skin, but it reports no new clinical results.

research Melanocytes in regenerative medicine applications and disease modeling

April 2024 in “Journal of translational medicine”

This review highlights the diverse roles of melanocytes in pigmentation, immunity, and hearing among other functions, their involvement in disorders, and their emerging potential in regenerative medicine, including applications in disease modeling and therapy development using advanced technologies.

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community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 2 years ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Been off Finasteride for two months, it definitely impacts sex drive.

33 upvotes 6 years ago

Stopping finasteride increased sex drive for some, while others had no change or different side effects. Despite concerns, many continue using finasteride for its effectiveness in preventing hair loss.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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