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    Glossary Disease Modeling

    scientific method to simulate and predict disease behavior

    Disease Modeling is a scientific method used to understand how diseases develop and spread within populations. It involves creating mathematical or computational simulations to predict the course of a disease, evaluate potential interventions, and inform public health strategies. This approach is crucial for planning responses to outbreaks and understanding the dynamics of diseases like COVID-19, influenza, or even conditions like alopecia.

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    1. Human epidermal neural crest stem cells as candidates for cell-based therapies, disease modeling, and drug discovery Birth defects research · 2014 · 13 citations
    2. Skin Organoids for Disease Modelling, Drug Screening and Regenerative Medicine: Recent Advances and Future Perspectives Wound Repair and Regeneration · 2026
    3. 779 Multicellular skin organoids as a unique modeling platform for skin physiology, injury, and disease Journal of Investigative Dermatology · 2024
    4. Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications International Journal of Molecular Sciences · 2015 · 33 citations
    5. Melanocytes in regenerative medicine applications and disease modeling Journal of translational medicine · 2024
    6. Mathematical Modeling of Alopecia Areata: Unraveling Hair Cycle Dynamics, Disease Progression, and Treatment Strategies Research Square · 2024
    7. Mathematical Modeling of Alopecia Areata: Unraveling Hair Cycle Dynamics, Disease Progression, and Treatment Strategies Applied Mathematics and Nonlinear Sciences · 2024
    8. 237 Unveiling Skin Cancers Pathophysiology via the Modeling of Xeroderma Pigmentosum Disease Modeling Using CRISPR-Cas9 Technology Journal of Investigative Dermatology · 2024
    9. 565 hiPSC-derived skin organoids as tools for disease modelling: characterization of the epidermal-dermal junction Journal of Investigative Dermatology · 2022
    10. Engineering immune-competent hair follicle microphysiological systems: from organoid assembly to dynamic immune modelling Frontiers in Bioengineering and Biotechnology · 2026
    11. Dermatological diseases from a genetic perspective Medizinische Genetik · 2023
    12. Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging Ageing Research Reviews · 2026
    13. Skin organoids: A new human model for developmental and translational research Experimental Dermatology · 2021 · 31 citations
    14. Generation of Skin Organoids: Potential Opportunities and Challenges Frontiers in cell and developmental biology · 2021 · 20 citations
    15. Hair follicle organoids: advances in construction, applications, and translational challenges Frontiers in Cell and Developmental Biology · 2026
    16. Development and Prospective Applications of 3D Membranes as a Sensor for Monitoring and Inducing Tissue Regeneration Membranes · 2023
    17. Biofabrication Technologies in Hair Neoformation Stem cell biology and regenerative medicine · 2022
    18. Bioengineered skin organoids: from development to applications Military Medical Research · 2023
    19. 454 Modeling epidermolysis bullosa simplex with cardiomyopathy using KLHL24-mutant pluripotent stem cells. Journal of Investigative Dermatology · 2025
    20. Part Three (Cure Most Diseases by Logical Nutrition Treatment): The Society Agent Simulating (SAS) & Usage of Oral and Dental Diseases to Predict Criminals Earlier Cognizance journal · 2023
    21. Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data Interdisciplinary sciences: computational life sciences · 2018 · 5 citations
    22. Biomedical applications of organoids in genetic diseases Medical Review · 2024
    23. 1430 Modeling the onset of senescence associated secretory phenotype predicts therapeutic targets Journal of Investigative Dermatology · 2018
    24. Stem cells, organoids and their applications for human diseases: Special issue of BMB Reports in 2023 Journal of Biochemistry and Molecular Biology · 2022 · 2 citations
    25. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of β-catenin in mice Genes & Development · 2008 · 556 citations
    26. 603 Pathological modeling of epidermolysis bullosa simplex (EBS) using induced pluripotent stem cells (iPSC) Journal of Investigative Dermatology · 2019
    27. 397 Predictive modeling of drug response and mechanism of action in alopecia areata clinical trials 2017
    28. Understanding skin morphogenesis across developmental, regenerative and evolutionary levels Experimental Dermatology · 2019 · 2 citations
    29. 706 Predictive modeling of patient response to JAK/STAT inhibitors and dynamic patient-matching 2019
    30. 1439 Development of a complex skin organ in human induced pluripotent stem cell-derived organoids 2023