Stem Cells, Organoids and Their Applications for Human Diseases: Special Issue of BMB Reports in 2023

    December 2022 in “ Journal of Biochemistry and Molecular Biology ”
    Kunyoo Shin
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    TLDR Organoids created from stem cells are used to model diseases, test drugs, and develop personalized and regenerative medicine.
    Recent advances in stem cell biology have enabled the creation of organoids, self-organizing 3D miniature tissues that mimic the structure and function of in vivo tissues. Organoids can be established from pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), or adult stem cells (AdSCs) for multiple tissues such as the intestine, brain, kidney, prostate, pancreas, liver, bladder, heart, and retina. Patient-derived tumor organoids have also been established from various human tumors. Bioengineering technologies and computational analyses have been applied to create more mature and complex organoids. Organoids are used for human disease modeling, drug screening, and the development of precision medicine and regenerative therapies. A review by Dr. Sekyu Choi and colleagues focuses on hair follicle stem cells (HFSC) and their aging, discussing the association of HFSC aging with hair loss and hair follicle regeneration.
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      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 1 year ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

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      in Research/Science  28 upvotes 9 months ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

      community Fun thought experiment about halting hair loss permamently

      in Research/Science  58 upvotes 6 months ago
      A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

      community Is there any new drug that looks promising ?

      in Research/Science  25 upvotes 8 months ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

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