Single-Cell RNA Sequencing Highlights a Contribution of Human Amniotic Mesenchymal Stem Cells-Derived Exosomes to Androgenetic Alopecia

    July 2025 in “ The FASEB Journal
    Xiaoyu Wang, Xiao‐Jian Han, Jie Wu, Qingyun Yuan, Juan Zhou, Zhenping Yu, Xin‐Hao Han, Xiao‐Hui Guan
    TLDR Human amniotic stem cell exosomes may effectively treat hair loss by promoting hair regrowth.
    The study explores the potential of human amniotic mesenchymal stem cells-derived exosomes (hAMSC-exo) in treating androgenetic alopecia (AGA) using a mouse model. It finds that hAMSC-exo can significantly promote hair regrowth by reversing hair follicle miniaturization and enhancing hair length and skin thickness. Single-cell RNA sequencing shows that hAMSC-exo treatment upregulates processes and pathways related to hair growth, such as cell differentiation and proliferation, and promotes hair follicle stem cell differentiation, accelerating the transition to the anagen phase. The study suggests that hAMSC-exo could be a promising therapeutic option for AGA, offering a more pronounced effect than hAMSC-conditioned medium.
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