Androgens Downregulate BMP2, Impairing the Inductive Role of Dermal Papilla Cells on Hair Follicle Stem Cells Differentiation

November 2020 in “ Molecular and Cellular Endocrinology ”

Julieta María Ceruti, Florencia Maia Oppenheimer, Gustavo José Leirós, María Eugenia Balañá

androgens bone morphogenetic proteins BMP2 BMP4 dermal papilla cells hair follicle stem cells differentiation dihydrotestosterone DHT androgenetic alopecia AGA BMP DPCs HFSCs

TLDR Androgens reduce BMP2, which weakens the ability of certain cells to help hair stem cells become different types of cells.

The document from January 1, 2021, detailed a study on the impact of androgens on hair follicle biology, specifically focusing on the role of bone morphogenetic proteins (BMP2 and BMP4) in dermal papilla cells (DPCs) and their influence on hair follicle stem cell (HFSC) differentiation. The study revealed that androgens, particularly dihydrotestosterone (DHT), downregulated BMP2 and BMP4 expression in DPCs, which in turn impaired the ability of DPCs to induce HFSC differentiation. However, the addition of BMP2 was able to restore the inductive capacity of DPCs and promote HFSC differentiation, even in the presence of DHT. This suggests that BMP2 has a positive paracrine effect on HFSC differentiation and could potentially counteract the negative effects of androgens in conditions like androgenetic alopecia (AGA). The study's findings highlight the importance of BMP2 in hair follicle development and suggest a potential therapeutic avenue for AGA treatment. The research did not specify the number of subjects as it was based on cellular models.

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