Androgens and Androgen Receptor Action in Skin and Hair Follicles

    September 2017 in “ Molecular and Cellular Endocrinology ”
    Julieta María Ceruti, Gustavo José Leirós, María Eugenia Balañá
    Studysummary This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 65

    1. Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia Molecular and Cellular Endocrinology · 2016
    2. Skin Steroidogenesis in Health and Disease Reviews in endocrine and metabolic disorders · 2016
    3. TR3 Is Preferentially Expressed by Bulge Epithelial Stem Cells in Human Hair Follicles Laboratory Investigation · 2016
    4. Androgens Induce Sebaceous Differentiation in Sebocyte Cells Expressing a Stable Functional Androgen Receptor Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2015
    5. Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis Journal of Dermatology · 2014
    6. The Female Pattern Hair Loss: Review of Etiopathogenesis and Diagnosis BioMed Research International · 2014
    7. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013
    8. Keratins Of The Human Occipital Hair Medulla: Androgenic Regulation Of In Vitro Hair Keratin K37 Expression British Journal of Dermatology · 2013
    9. Increased Androgen Receptor Messenger RNA in Frontal-Parietal Hair Follicles of Women with Androgenetic Alopecia Genetics and Molecular Research · 2013
    10. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    11. New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today's Pre-Clinical Data into Tomorrow's Daily Clinical Practice Current pharmaceutical biotechnology · 2012
    12. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    13. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    14. Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis Clinical and Experimental Dermatology · 2011
    15. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    16. Evidence of Increased DNA Methylation of the Androgen Receptor Gene in Occipital Hair Follicles from Men with Androgenetic Alopecia British Journal of Dermatology · 2011
    17. Therapeutic Hotline: Genetic Variations in the Androgen Receptor Gene and Finasteride Response in Women with Androgenetic Alopecia Mediated by Epigenetics Dermatologic Therapy · 2011
    18. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    19. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    20. Effect of Dihydrotestosterone on the Upregulation of Inflammatory Cytokines in Cultured Sebocytes Archives of Dermatological Research · 2009
    21. The Skin as an Endocrine Organ Dermato-endocrinology · 2009
    22. Hormones and the Pilosebaceous Unit Dermato-endocrinology · 2009
    23. Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009
    24. Stem Cell Factor/c-Kit Signaling in Normal and Androgenetic Alopecia Hair Follicles Journal of Endocrinology · 2008
    25. Baldness, Benign Prostate Hyperplasia, Prostate Cancer, and Androgen Levels The Aging Male · 2008
    26. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    27. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    28. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    29. Sexual Hormones in Human Skin Hormone and metabolic research · 2007
    30. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    31. Expression of Androgen Receptor Coactivator ARA70/ELE1 in Androgenic Alopecia Journal of Cutaneous Pathology · 2005
    32. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    33. Estrogen Functions in Skin and Skin Appendages Expert Opinion on Therapeutic Targets · 2005
    34. The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia Cancer Epidemiology, Biomarkers & Prevention · 2005
    35. Sex Steroid Hormone Receptors in Human Skin Appendages and Their Neoplasms Endocrine Journal · 2005
    36. An Update on Congenital Adrenal Hyperplasia Annals of the New York Academy of Sciences · 2004
    37. Androgen Action on Human Skin – From Basic Research to Clinical Significance Experimental dermatology · 2004
    38. Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin Physiological Genomics · 2004
    39. Estrogens And The Hair Follicle Journal der Deutschen Dermatologischen Gesellschaft · 2004
    40. Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes Journal of Investigative Dermatology · 2004
    41. Estrogens and Human Scalp Hair Growth: More Questions Than Answers Journal of Investigative Dermatology · 2004
    42. The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003
    43. Androgenetic Alopecia in Women Journal of Investigative Dermatology Symposium Proceedings · 2003
    44. Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    45. Regulatory Roles of Androgens in Cutaneous Wound Healing Thrombosis and Haemostasis · 2003
    46. Update and Future of Systemic Acne Treatment Dermatology · 2003
    47. Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    48. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    49. Androgen Receptor-Mediated Inhibition of Cutaneous Wound Healing ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2002
    50. 17α-Estradiol Induces Aromatase Activity in Intact Human Anagen Hair Follicles Ex Vivo Experimental Dermatology · 2002
    51. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    52. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    53. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001
    54. Immunolocalization of 5α-Reductase Isozymes in Acne Lesions and Normal Skin Archives of dermatology · 2000
    55. Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells British journal of dermatology/British journal of dermatology, Supplement · 1999
    56. Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    57. Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands Journal of Investigative Dermatology · 1998
    58. Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne Journal of Cutaneous Medicine and Surgery · 1998
    59. 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla Archives of Dermatological Research · 1998
    60. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    61. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    62. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995
    63. Androgens and Human Hair Growth Clinical endocrinology · 1994
    64. Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp Journal of Endocrinology/Journal of endocrinology · 1992
    65. Steroid Chemistry and Hormone Controls During the Hair Follicle Cycle Annals of the New York Academy of Sciences · 1991

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