Effect of Dihydrotestosterone on the Upregulation of Inflammatory Cytokines in Cultured Sebocytes

    December 2009 in “ Archives of Dermatological Research ”
    Weon Ju Lee, H. Jung, Seong Geun, Byung Soo Kim, Seok Jong Lee, Do Won Kim, Moon Kyu Kim, Jung Chul Kim
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    TLDR Dihydrotestosterone increases certain inflammatory signals in skin cells, potentially contributing to acne.
    The study examined how dihydrotestosterone (DHT) affects the production of inflammatory cytokines in sebocytes, which are linked to acne development. Using immunohistochemistry and RT-PCR, the researchers found that DHT treatment increased the levels of IL-6 and TNF-α, both in protein and mRNA expression, but did not affect IL-1 levels. These findings indicate that DHT may play a role in acne by promoting the production of specific proinflammatory cytokines in sebocytes. The exact number of sebocyte cultures used was not provided in the study.
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