TLDR Men with hair loss have more DNA changes in back-of-head hair follicles, possibly protecting them from thinning.
The study found that men with androgenetic alopecia (AGA) have higher levels of DNA methylation of the androgen receptor (AR) gene in occipital hair follicles compared to vertex follicles. This may protect occipital hairs from miniaturization and hair loss. The study suggests that this finding could lead to the development of therapeutic strategies for AGA, but further analysis is needed.
63 citations,
November 1999 in “British journal of dermatology/British journal of dermatology, Supplement” Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.
227 citations,
January 1998 in “Journal of Endocrinology” Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
416 citations,
September 1997 in “Journal of Investigative Dermatology” People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
January 2014 in “American Journal of Medicine and Medical Sciences” Minoxidil, originally a blood pressure medication, is effective in treating hair loss in men and women, with different strengths recommended for each.
19 citations,
January 1997 in “Dermatologic Clinics” Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.
