Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage

    November 2013 in “ PLOS ONE ”
    Yi‐Chien Yang, Hung-Chun Fu, Ching‐Yuan Wu, Kuo-Ting Wei, Ko-En Huang, Hong-Yo Kang
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    TLDR Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.
    The study explored the impact of androgen receptor (AR) signaling on the early aging (senescence) of human dermal papilla cells (DPCs), which are essential for hair growth and are involved in androgenetic alopecia (AGA). It was found that DPCs from AGA patients exhibited more signs of premature senescence than those from non-AGA individuals. Androgen exposure, particularly dihydrotestosterone (DHT), was shown to induce premature senescence in DPCs from non-balding scalp areas and the transitional zone of balding scalp, but not in beard follicles. Overexpression of AR in DPCs led to increased premature senescence, higher levels of p16/Nk4a, and DNA damage markers, while reducing AR expression had the opposite effect. The study concluded that androgen/AR signaling promotes premature senescence in DPCs via DNA damage and the p16INK4 axis, pointing to potential targets for AGA treatment. The exact number of participants from whom DPCs were derived was not mentioned.
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      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  735 upvotes 3 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

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      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The mechanism of androgenic alopecia

      in Research/Science  34 upvotes 4 weeks ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

      community Creatine is the opposite of minoxidil !

      in Research/Science  320 upvotes 1 week ago
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