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Glossaryp16 (p16INK4a)

inhibits cell division by regulating cyclin-dependent kinases

p16, also known as CDKN2A, is a protein that acts as a tumor suppressor by regulating the cell cycle. It inhibits cyclin-dependent kinases (CDKs), which are enzymes that promote cell division, thereby preventing uncontrolled cell growth that can lead to cancer.

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research Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression

141 citations , November 2007 in “Journal of Investigative Dermatology”

Balding cells age faster due to stress, suggesting stress-targeting treatments for hair loss.

research Knockout of p16INK4a Promotes Aggregative Growth of Dermal Papilla Cells

2 citations , October 2017 in “Revista Da Associacao Medica Brasileira”

Removing p16INK4a from skin cells can lead to faster and more clumped growth, which might help with hair growth.

research Induction of Cellular Senescence and Hair Follicle Stem Cell Dysfunction Upon p14ARF and p16Ink4a Expression in the Skin

July 2014 in “European Journal of Cancer”

p14ARF and p16Ink4a cause hair follicle stem cell aging and dysfunction.

research Molecular Regulation of Melanocyte Senescence

85 citations , July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

research Stem Cell Rejuvenation and the Role of Autophagy in Age Retardation by Caloric Restriction: An Update

19 citations , July 2018 in “Mechanisms of Ageing and Development”

Eating less can slow aging and help keep stem cells healthy by cleaning out damaged cell parts.

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