TLDR The protein ARA70/ELE1 is involved in male pattern baldness, and lower levels of its short form may lead to hair thinning.
The study examined the expression of ARA70/ELE1, a coactivator of the androgen receptor, in the scalp of seven men with androgenic alopecia. It found that ARA70/ELE1 is present in all epithelial hair structures except the inner root sheath, with the short form (ARA70B/ELE1ß) being expressed in the dermal papilla and hair bulb. Notably, expression of ARA70B/ELE1ß was weaker in the dermal papilla of balding areas. The results suggest that ARA70/ELE1 plays a role in androgenic alopecia and that the reduced expression of the short form, ARA70B/ELE1ß, may contribute to the hair follicle miniaturization seen in this condition.
Cited in this study
8 / 8 results
229 citations
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January 1998 in “Journal of Endocrinology” Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
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September 1997 in “Journal of Investigative Dermatology” People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
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January 1997 in “Endocrinology” Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.
20 citations
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September 2005 in “Journal of Cutaneous Pathology” The protein ARA70/ELE1 is involved in male pattern baldness, and lower levels of its short form may lead to hair thinning.
