Expression of Androgen Receptor Coactivator ARA70/ELE1 in Androgenic Alopecia

August 2005 in “ Journal of Cutaneous Pathology ”

Peng Lee, Changcheng Zhu, Neil S. Sadick, A. Hafeez Diwan, Peter G. Zhang, Jinsong Liu, Victor G. Prieto

androgen receptor ARA70 ELE1 androgenic alopecia epithelial hair structures inner root sheath ARA70B ELE1ß dermal papilla hair bulb hair follicle miniaturization

TLDR The protein ARA70/ELE1 is involved in male pattern baldness, and lower levels of its short form may lead to hair thinning.

The study examined the expression of ARA70/ELE1, a coactivator of the androgen receptor, in the scalp of seven men with androgenic alopecia. It found that ARA70/ELE1 is present in all epithelial hair structures except the inner root sheath, with the short form (ARA70B/ELE1ß) being expressed in the dermal papilla and hair bulb. Notably, expression of ARA70B/ELE1ß was weaker in the dermal papilla of balding areas. The results suggest that ARA70/ELE1 plays a role in androgenic alopecia and that the reduced expression of the short form, ARA70B/ELE1ß, may contribute to the hair follicle miniaturization seen in this condition.

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1 / 1 results

research Expression of Androgen Receptor Coactivator ARA70/ELE1 in Androgenic Alopecia

20 citations , August 2005 in “Journal of Cutaneous Pathology”

The protein ARA70/ELE1 is involved in male pattern baldness, and lower levels of its short form may lead to hair thinning.

Expression of Androgen Receptor Coactivator ARA70/ELE1 in Androgenic Alopecia

Research cited in this study

research Androgenetic Alopecia: Analysis of Proliferation and Apoptosis

research Molecular Mechanisms of Androgenetic Alopecia

research The Genetics of Androgenetic Alopecia

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

research Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp

research The Biology of Hair Follicles

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

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