Estrogen Functions in Skin and Skin Appendages
June 2005
in “
Expert Opinion on Therapeutic Targets
”
oestrogens keratinocytes UVB radiation biosynthesis intracellular receptors cell surface receptors gene transcription rapid signalling pathways anagen phase female pattern hair loss sebum production skin cancer estrogens skin cells UV radiation hormone production internal receptors surface receptors gene expression quick signalling pathways growth phase female hair loss oil production skin tumors
TLDR Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.
The document from 2005 explores the multifaceted role of oestrogens in skin health and function, detailing their impact on various skin cells and appendages. Oestrogens are shown to delay skin aging, enhance wound healing, and improve inflammatory skin disorders, while also preventing apoptosis in keratinocytes caused by UVB radiation. The paper discusses the biosynthesis of oestrogens and their action through intracellular and cell surface receptors, affecting gene transcription and rapid signalling pathways. It also notes oestrogens' ability to inhibit hair growth and prolong the anagen phase, which has implications for treating female pattern hair loss. Furthermore, oestrogens are found to reduce sebum production and may have a protective role against skin cancer. The complexity of oestrogen action is underscored by the presence of multiple receptors and the involvement of various signalling pathways. However, the document does not provide specific numbers of participants or subjects in the studies it references.
