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research Gender Differences in Production and Circulating Levels of Sex Hormones and Their Impact on Aging Skin

September 2014 in “Springer eBooks”

This review discusses how sex hormone levels and local steroid synthesis influence gender differences in aging skin, reporting no new clinical results.

research 837 Characterization of cutaneous hormone production through analysis of skin secretions

July 2022 in “Journal of Investigative Dermatology”

This study developed a method to quantify hormones in skin secretions and found that hormonal composition varies by sex and anatomical site.

research Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production

7 citations , September 2022 in “Communications biology”

This research found that Leydig cells significantly rely on synthesizing omega-6 HUFAs to support male steroid hormone production, highlighting a new role for these fatty acids in the male reproductive system.

research Efficacy of serum anti-mullerian hormone (AMH) levels for prediction of polycystic ovary syndrome (PCOS) and its association with clinical, biochemical and hormonal parameters

10 citations , September 2022 in “Indian Journal of Clinical Biochemistry”

Evaluation of the Efficacy and Threshold of Serum Anti-Mullerian Hormone Levels for Diagnosis and Prediction of Polycystic Ovary Syndrome Among Indian Women

research Evaluation of the Efficacy and Threshold of Serum Anti-mullerian Hormone (AMH) Levels for Diagnosis and Prediction of Polycystic Ovary Syndrome (PCOS) Among Indian Women.

January 2022 in “Research Square (Research Square)”

This study determined that serum AMH levels are higher in women with PCOS compared to controls and may serve as a diagnostic marker for ovarian dysfunction alone or with other tools.

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Community Join

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community Claim: Insulin resistance increases the enzyme that creates DHT and affects the liver's ability to control hormones

in Research/Science 4 upvotes 11 months ago

Insulin resistance may increase DHT production, contributing to hair loss, and addressing it through diet, nutrients, and natural DHT blockers like saw palmetto and pumpkin seed oil could help reverse hair loss. Some users prefer medications like finasteride for more effective results.

community Planning to take a break from Fin for a 2 months then start with Pyrilutamide - What hormone levels to test?

2 upvotes 3 years ago

The user plans to pause finasteride for two months to test its effects on mood and productivity, then switch to Pyrilutamide while monitoring hormone levels. Concerns are raised about potential hair loss and the effectiveness of Pyrilutamide compared to finasteride.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community RU58841 to stop excessive oil production?

in Research/Science 7 upvotes 2 years ago

The user discusses using Minoxidil for hair loss and is considering RU58841 to reduce excessive oil production. They seek advice on RU58841's effectiveness in blocking sebum production.

community The day they make a pill that only targets DHT production in the scalp

in Finasteride/Dutasteride 29 upvotes 1 year ago

Reducing DHT in the scalp is ideal for hair retention, with topical finasteride and dutasteride being common treatments. Some users report side effects like reduced libido, while others experiment with higher doses for regrowth.

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Learn

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learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn sh-Polypeptide-7

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? Applying Estradiol directly to the scalp may help with hormone-related hair thinning.

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Sulforaphane

compound from cruciferous vegetables has some mild effects on DHT

learn Centella

Sensitive to hormones? A centella scalp mask may help ease hidden inflamm Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

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