Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

June 2003 in “ Journal of Investigative Dermatology Symposium Proceedings ”

Shigeki Inui, Yoshimitsu Fukuzato, Takeshi Nakajima, Kunihiko Yoshikawa, Satoshi Itami

androgenetic alopecia TGF-β1 dermal papilla cells keratinocytes hair growth suppression AGA transforming growth factor beta 1 DPCs KCs

TLDR TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

This study investigated the pathomechanism of androgenetic alopecia (AGA) by establishing an in vitro coculture model of human dermal papilla cells (DPCs) from AGA and keratinocytes (KCs). The study found that androgen-inducible TGF-β1 derived from DPCs mediates hair growth suppression in AGA. The study suggests that targeting TGF-β1 may be a potential therapeutic strategy for androgenetic alopecia.

View this study on jidsponline.org →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Conditional Epidermal Expression of TGFβ1 Blocks Neonatal Lethality but Causes a Reversible Hyperplasia and Alopecia

103 citations , July 2001 in “Proceedings of the National Academy of Sciences”

TGFβ1 expression in skin causes hair loss and skin thickening, but these effects are reversible.

research Lack of Androgen Receptor Transcriptional Activity in Human Keratinocytes

30 citations , June 2000 in “Journal of dermatological science”

Human keratinocytes do not naturally respond to androgens.

research Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells

63 citations , November 1999 in “British journal of dermatology/British journal of dermatology, Supplement”

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

research Roles of Testosterone in the Growth of Keratinocytes Through Bald Frontal Dermal Papilla Cells

21 citations , January 1999 in “Endocrine”

research Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro

140 citations , December 1998 in “Journal of Investigative Dermatology”

Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.

research Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling

148 citations , October 1997 in “Journal of Investigative Dermatology”

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

33 citations , January 1997 in “Endocrinology”

Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

research Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp

124 citations , April 1992 in “Journal of Endocrinology/Journal of endocrinology”

Beard hair follicles have more androgen receptors than non-balding scalp hair follicles.

research Hair Follicles and Associated Glands as Androgen Targets

53 citations , May 1986 in “Clinics in endocrinology and metabolism”

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

Related Research

5 / 5 results

research Androgenetic Alopecia-Associated Cytokines

July 2014 in “International Journal of Dermatology and Venereology”

Cytokines play a key role in hair loss by affecting hair growth.

Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

research Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

56 citations , September 2013 in “Journal of Biochemistry and Molecular Biology”

Androgens increase a growth factor in hair cells by creating reactive oxygen species, and antioxidants might help treat hair loss.

research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

78 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

190 citations , October 2002 in “The FASEB journal”

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

Research cited in this study

research Conditional Epidermal Expression of TGFβ1 Blocks Neonatal Lethality but Causes a Reversible Hyperplasia and Alopecia

research Lack of Androgen Receptor Transcriptional Activity in Human Keratinocytes

research Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells

research Roles of Testosterone in the Growth of Keratinocytes Through Bald Frontal Dermal Papilla Cells

research Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro

research Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

research Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp

research Hair Follicles and Associated Glands as Androgen Targets

Related Community Posts Join

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

community The Real Cause Of Androgenetic Alopecia

community ladies and gentlmen, vitamin E is your hair follicles second best friend

community My Theory Of Androgenic Alopecia

community Natural Remedies: Polyphenols and Hair Loss

community The Effect of Intradermal Botox on Androgenetic Alopecia and Its Possible Mechanism (Journal of the American Academy of Dermatology (2020)

Related Research

research Androgenetic Alopecia-Associated Cytokines

research Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells