Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling

October 1997 in “ Journal of Investigative Dermatology ”

Ralf Paus, Kerstin Foitzik, Pia Welker, Silvia Bulfone‐Paus, Stefan B. Eichmüller

Studysummary TGF-β receptors are crucial for hair follicle development.

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The study examined the expression of Transforming Growth Factor-β Receptor Type I and Type II during murine hair follicle development and cycling, focusing on neonatal morphogenesis and hair cycle induction via depilation and cyclosporin A. It was discovered that TGF-βRII expression was limited to epithelial cells during morphogenesis. Using immunohistology and semi-quantitative RT-PCR, the research analyzed 30-50 hair follicles from 3-5 mice per developmental stage. The findings offered insights into the signaling events in hair follicle development, emphasizing the significance of TGF-β receptors in hair biology.

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