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GlossaryKeratinocytes (KCs)

cells in the epidermis that produce protective keratin protein

Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. These cells produce keratin, a protein that helps protect the skin from environmental damage, pathogens, and water loss. They play a crucial role in the skin's barrier function and are involved in wound healing and the formation of hair and nails.

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Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

190 citations, October 2002 in “The FASEB journal”

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

78 citations, June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

research Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid

42 citations, January 2017 in “Stem cells international”

Adding hyaluronic acid helps create larger artificial hair follicles in the lab.

research Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration

30 citations, November 2020 in “Journal of Advanced Research”

Conditioned medium from keratinocytes can improve hair growth potential in cultured dermal papilla cells.

research Microscopy-Guided Laser Ablation for the Creation of Complex Skin Models with Folliculoid Appendages

5 citations, December 2020 in “Bioengineering & translational medicine”

Researchers used a laser to create advanced skin models with hair-like structures.

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community How are people getting DUT so easily?

in Finasteride/Dutasteride 15 upvotes 1 month ago

Dutasteride is hard to get in Europe due to prescription rules, leading some to consider online pharmacies or travel. Users discuss alternatives like private doctors and compare it to finasteride, expressing concerns about side effects and effectiveness.