Estrogens And The Hair Follicle
May 2004
in “
Journal der Deutschen Dermatologischen Gesellschaft
”
estrogens 17ß-estradiol E2 hair follicle cycling hair growth estrogen signaling telogen effluvium estrogen receptors skin quality wound healing hair shaft elongation telogen rate anagen phase scalp skin E2-responsive genes estradiol hair growth inhibitors hair growth stimulants hair cycle hair loss treatment skin improvement wound repair hair growth phase hair shedding phase
TLDR Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.
The document from 2004 reviews the role of estrogens, particularly 17ß-estradiol (E2), in hair follicle cycling and hair growth, highlighting the complexity of estrogen signaling and its effects on hair biology. Estrogens are known to act as hair growth inhibitors in most species and are used to treat telogen effluvium. The review discusses the expression of estrogen receptors in the skin, their potential target genes, and their interaction with other hormones and factors. It also notes that estrogens improve skin quality and may influence wound healing. In terms of hair growth, E2 has been found to inhibit hair shaft elongation in females but stimulate it in males, and to decrease the telogen rate and prolong the anagen phase in human scalp skin. The document emphasizes that the exact mechanisms of estrogen's effects on hair follicles are not fully understood and that further research is needed, particularly regarding sex-dependent differences and the modulation of E2-responsive genes.
