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Glossary Estrogen Receptors

proteins that bind estrogen, influencing cell behavior and function

Estrogen receptors (ER) are proteins found inside and on the surface of certain cells that bind to the hormone estrogen. When estrogen binds to these receptors, it can influence the behavior of the cell, including growth, differentiation, and function. These receptors play a crucial role in various physiological processes, including reproductive health, bone density, and even hair growth. In medical research, ERs are significant in understanding conditions like breast cancer, where the presence of these receptors can influence treatment options.

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Research

5 / 1000+ results

research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.

154 citations , October 1996 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that 17-beta-estradiol inhibits hair growth in mice by blocking hair follicles in the telogen phase, whereas an estrogen receptor antagonist promotes hair growth by initiating anagen.

research The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

130 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that estrogen receptor beta, not alpha, is the main mediator of estrogen action in human skin and hair follicles, suggesting a distinct role in these tissues.

research Polymorphisms of the Androgen Receptor Gene and the Estrogen Receptor β Gene Are Associated with Androgen Levels in Women1

93 citations , June 2001 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that serum androgen levels in premenopausal women may be influenced by genetic variants of the androgen receptor and estrogen receptor β genes.

research Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-α Is Checked by ERβ Signaling

92 citations , February 2005 in “Endocrinology”

This study found that estrogen receptor beta plays a significant role in murine hair growth control, potentially acting as a silencer of estrogen receptor alpha's catagen-promoting effects.

research Expression patterns of three estrogen receptor genes during zebrafish (Danio rerio) development: evidence for high expression in neuromasts

77 citations , April 2004 in “Gene expression patterns”

This study observed specific expression patterns of three zebrafish estrogen receptor genes during development, highlighting robust co-expression of esr2a and esr2b in primary neuromasts, branchial arches, and other tissues.

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Community Join

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community Theaflavin (Black Tea Extract) reduce DHT, androgen receptor activity and estrogen

6 upvotes 3 years ago

Theaflavin, a black tea extract, may inhibit DHT and androgen receptor activity, but its effectiveness for hair loss is debated. Users report no significant improvement with theaflavin, while some find beta sitosterol helpful.

community Alternatives/unorthodox hairloss protocols to the big three

in Chat 1 upvotes 8 months ago

The conversation discusses alternative and unorthodox hair loss treatments, including RU58841, nandrolone, and dianabol, as well as theoretical approaches involving high doses of estrogen and selective estrogen receptor modulators. These methods are considered extreme and potentially harmful but are explored for those unable to tolerate traditional 5-alpha reductase inhibitors.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community How insane would it be to take estrogen until all your hair grows back, then getting off of it and taking fin or dut to maintain

in Chat 69 upvotes 9 months ago

Using estrogen for hair regrowth is considered ineffective and risky, with potential side effects like breast growth and hormonal changes. Alternatives like finasteride, dutasteride, and minoxidil are suggested, but estrogen is not recommended unless transitioning.

community Injecting estrogen for hairline regrow

268 upvotes 1 year ago

A user plans to undergo a temporary MtF transformation to regrow hair, using estrogen, RU58841, and Dutasteride, then revert with testosterone. Many users criticize the plan, suggesting alternatives like hair transplants, and emphasize that estrogen is not a reliable solution for hair regrowth.

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Learn

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learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Alfatradiol

Alfatradiol: What does a form of estrogen have to do with hair loss in men? Alfatradiol (17α-estradiol) is a topical hormone sold without prescription in German pharmacies, licensed there for mild androgenetic alopecia, and not FDA-approved. The controlled trial evidence is in women, where hair density and thickness stayed nearly unchanged over 6 months while minoxidil improved them (the trial had no placebo group); no comparable placebo-controlled trial in men appears to have been published.

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