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    Glossary Estrogen Receptor Alpha

    protein inside cells that binds to estrogen hormone

    Estrogen Receptor Alpha (ERα) is a protein found inside cells that binds to the hormone estrogen. This receptor is crucial for regulating various biological processes, including reproductive functions and the development of certain tissues. In the context of hair and alopecia, ERα can influence hair growth and loss, as estrogen plays a role in the hair growth cycle.

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    Research 10 of 1000+

    1. The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta? Journal of Investigative Dermatology · 2006 · 65 citations
    2. Minoxidil May be a Partial Agonist of Estrogen Receptor Alpha microPublication · 2026
    3. Ferulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells Scientific Reports · 2026
    4. Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework Frontiers in Toxicology · 2025
    5. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-α Is Checked by ERβ Signaling Endocrinology · 2005 · 92 citations
    6. Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats Reproductive Biology and Endocrinology · 2025
    7. Complex Extract of Polygonatum sibiricum and Nelumbinis semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model Nutrients · 2023
    8. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified Experimental Dermatology · 2012 · 18 citations
    9. Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing International Journal of Molecular Medicine · 2015 · 23 citations
    10. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proceedings of the National Academy of Sciences of the United States of America · 1996 · 154 citations
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    Community 10 of 192

    1. If we lose hair because of our sensitivity to DHT, then why are we trying to reduce DHT when our sensitive androgen receptors are the culprit? Reddit · 6 Apr 2022
    2. High Estrogen causing hair loss? Reddit · 27 Aug 2023
    3. Long term finasteride users; Did you notice any improvement after 2 years? Reddit · 11 Apr 2023
    4. Stop expecting results in 2 months! Reddit · 5 May 2024
    5. Has anyone ever tried using (all topicals) finasteride + minoxidil + rosemary oil + castor oil + stemoxydine all over the course of a few months/years? Reddit · 4 Apr 2024
    6. Creatine's effect on Hair Loss and DHT Reddit · 3 Mar 2024
    7. Trying to understand finasteride side effects and post finasteride syndrome Reddit · 31 Oct 2020
    8. How to Keep Your Hair on Steroids Reddit · 10 Sept 2024
    9. Why wouldn't it be recommended to just jump from finasteride to dutasteride? Reddit · 31 Jul 2024
    10. DHT and 5AR respect post, it's importance within the brain Reddit · 3 Mar 2024
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    Learn 2 of 5

    1. Estradiol Estrogen hormone, prescribed in tablet, patch and gel forms
    2. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
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