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Glossary Aromatase Inhibitors

block estrogen production by inhibiting the aromatase enzyme

Aromatase Inhibitors (AIs) are a class of drugs that block the enzyme aromatase, which is responsible for converting androgens into estrogens. By reducing estrogen levels, AIs are commonly used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women, as estrogen can promote the growth of certain types of breast cancer cells.

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Research

5 / 1000+ results

research Management of Sexual Dysfunction in Postmenopausal Breast Cancer Patients Taking Adjuvant Aromatase Inhibitor Therapy

90 citations , December 2007 in “Current Oncology”

This review discusses management strategies for sexual side effects of aromatase inhibitors in postmenopausal breast cancer patients and reports no original clinical findings.

research Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: A possible androgenic bone protective effects induced by exemestane

50 citations , December 2006 in “Bone”

This study found that the steroidal aromatase inhibitor exemestane stimulated proliferation of human osteoblast cells, suggesting both androgen receptor-dependent and independent pathways are involved.

research Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor

44 citations , December 2005 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that testosterone is converted to estrogenic steroids in vitro without aromatase involvement, suggesting that combining 5α-reductase and aromatase inhibitors might reduce estrogenic steroids more completely in vivo.

research Intravaginal Testosterone Improves Sexual Satisfaction and Vaginal Symptoms Associated With Aromatase Inhibitors

37 citations , September 2018 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that intravaginal testosterone significantly improved sexual satisfaction and reduced dyspareunia in postmenopausal women using aromatase inhibitors, with no effect on urinary incontinence.

research Aromatase inhibitor therapy and hair loss among breast cancer survivors

34 citations , November 2013 in “Breast Cancer Research and Treatment”

This study found that female breast cancer survivors using aromatase inhibitors were observed to have a higher likelihood of experiencing hair loss and thinning compared to those not treated with these drugs.

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Community Join

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community Aromatise inhibitor for finasteride-estrogen side effects?

5 upvotes 4 years ago

A user experienced mild side effects from 0.5mg finasteride daily, including increased estradiol and minor gynecomastia. They are considering taking a low dose of exemestane to reduce estrogen levels.

community Hormone Management Advice - Aromatase Inhibitors , SHBG Blockers

in Finasteride/Dutasteride 5 upvotes 1 year ago

The user plans to switch from minoxidil to finasteride or dutasteride for hair loss, while managing hormones with aromatase inhibitors and SHBG blockers. They seek advice on the best options for these treatments, considering past side effects and future therapies.

community What happens if you combine dutasteride and a aromataze inhibitor?

4 upvotes 7 years ago

Combining dutasteride and an aromatase inhibitor may increase testosterone levels significantly, potentially enhancing athletic performance but also posing health risks like elevated blood pressure and worsened cholesterol. The user is experimenting with dutasteride, anastrozole, minoxidil, and ketoconazole shampoo to manage hair loss and estradiol levels, while monitoring side effects and hormone levels.

community Finasteride with an aromatase inhibitor

5 upvotes 6 years ago

The conversation is about managing potential gynecomastia from finasteride use. The user considers using an aromatase inhibitor and plans to check hormone levels.

community Shouldn't it be standard practice for anyone on Fin to take zinc (or another aromatase inhibitor)?

8 upvotes 10 years ago

Taking zinc may reduce side effects of finasteride, such as gyno, by preventing testosterone from converting to estrogen. Some users report improved symptoms with zinc, but excessive intake can cause issues like copper deficiency or stomach problems.

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