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GlossaryAromatase Inhibitors

block estrogen production by inhibiting the aromatase enzyme

Aromatase Inhibitors (AIs) are a class of drugs that block the enzyme aromatase, which is responsible for converting androgens into estrogens. By reducing estrogen levels, AIs are commonly used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women, as estrogen can promote the growth of certain types of breast cancer cells.

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research Effects of Aromatase Inhibitors on Human Osteoblast and Osteoblast-Like Cells: A Possible Androgenic Bone Protective Effect Induced by Exemestane

50 citations, December 2006 in “Bone”

Exemestane may protect bones by stimulating osteoblast growth through androgen-related pathways.

research Intravaginal Testosterone Improves Sexual Satisfaction and Vaginal Symptoms Associated With Aromatase Inhibitors

37 citations, September 2018 in “The Journal of Clinical Endocrinology and Metabolism”

Intravaginal testosterone cream improves sexual satisfaction and reduces vaginal discomfort in postmenopausal women on breast cancer treatment without affecting hormone levels.

research Aromatase Inhibitors Induce Male Pattern Hair Loss in Women

19 citations, May 2013 in “Annals of Oncology”

Aromatase inhibitors cause male pattern hair loss in women.

research Management of Sexual Dysfunction in Postmenopausal Breast Cancer Patients Taking Adjuvant Aromatase Inhibitor Therapy

90 citations, December 2007 in “Current Oncology”

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

research The Safety of Local Hormonal Treatment for Vulvovaginal Atrophy in Women With Estrogen Receptor-Positive Breast Cancer on Adjuvant Aromatase Inhibitor Therapy: Meta-Analysis

18 citations, August 2019 in “Clinical breast cancer”

Local hormonal treatment for vulvovaginal atrophy is likely safe for women with estrogen receptor-positive breast cancer on aromatase inhibitors.

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community Can aromatase inhibitors make dutasteride/finasteride useless?

in Finasteride/Dutasteride 9 upvotes 8 months ago

The conversation discusses using aromatase inhibitors with dutasteride or finasteride for hair loss, which can prevent testosterone from turning into estrogen but may lead to increased DHT and potentially make finasteride less effective. There's concern about proper dosing and side effects like gynecomastia and emotional changes.

community After almost 4 months on fin, it looks like I might be unlucky enough to develop early sings of gyno...

in Finasteride/Dutasteride 6 upvotes 4 years ago

After nearly four months on finasteride, a user noticed improved hair quality but developed nipple puffiness, suggesting early signs of gynecomastia. They considered switching to other treatments like CB-03-01 or RU58841 and contemplated consulting an endocrinologist about aromatase inhibitors.

community Estrogen lowering supplements while on Finasteride?

in Treatment 7 upvotes 3 years ago

The conversation discusses using aromatase inhibiting supplements like DIM and Grape Seed extract while on finasteride for hair loss treatment. Users share their experiences and opinions on combining these supplements with finasteride.

community Completely defeated after trying so hard with topical finasteride.

in Finasteride/Dutasteride 24 upvotes 1 year ago

A user who has tried multiple treatments for hair loss, including oral and topical finasteride and liposomal finasteride, but experienced severe side effects in each case; the user is considering trying RU58841 or aromatise inhibitors as alternatives.

community Does anyone manage to keep the estradiol under control while on fin ? I'm talking in the normal range

in Chat 3 upvotes 5 months ago

Managing estradiol levels while using finasteride. Treatments discussed include Minoxidil, finasteride, and RU58841.

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