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GlossaryAromatase Inhibitors

block estrogen production by inhibiting the aromatase enzyme

Aromatase Inhibitors (AIs) are a class of drugs that block the enzyme aromatase, which is responsible for converting androgens into estrogens. By reducing estrogen levels, AIs are commonly used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women, as estrogen can promote the growth of certain types of breast cancer cells.

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research Effects of Aromatase Inhibitors on Human Osteoblast and Osteoblast-Like Cells: A Possible Androgenic Bone Protective Effect Induced by Exemestane

50 citations , December 2006 in “Bone”

Exemestane may protect bones by stimulating osteoblast growth through androgen-related pathways.

research Intravaginal Testosterone Improves Sexual Satisfaction and Vaginal Symptoms Associated With Aromatase Inhibitors

37 citations , September 2018 in “The Journal of Clinical Endocrinology and Metabolism”

Intravaginal testosterone cream improves sexual satisfaction and reduces vaginal discomfort in postmenopausal women on breast cancer treatment without affecting hormone levels.

research Aromatase Inhibitors Induce Male Pattern Hair Loss in Women

19 citations , May 2013 in “Annals of Oncology”

Aromatase inhibitors cause male pattern hair loss in women.

research A Phase II Study of Vaginal Testosterone Cream Versus Estring for Vaginal Dryness or Decreased Libido in Women with Early Stage Breast Cancer Treated with Aromatase Inhibitors

9 citations , December 2009 in “Cancer Research”

Both vaginal testosterone cream and Estring effectively manage vaginal dryness in women with early-stage breast cancer on aromatase inhibitors.

research Design, Synthesis, and Structure-Activity Relationship Studies on Steroidal Aromatase and 5α-Reductase Inhibitors as Anti-Tumor Agents

December 2013 in “Estudo Geral (Universidade de Coimbra)”

Modified steroidal inhibitors showed promise in treating hormone-dependent cancers.

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community Can aromatase inhibitors make dutasteride/finasteride useless?

in Finasteride/Dutasteride 9 upvotes 1 year ago

The conversation discusses using aromatase inhibitors with dutasteride or finasteride for hair loss, which can prevent testosterone from turning into estrogen but may lead to increased DHT and potentially make finasteride less effective. There's concern about proper dosing and side effects like gynecomastia and emotional changes.

community Hormone Management Advice - Aromatase Inhibitors , SHBG Blockers

in Finasteride/Dutasteride 3 upvotes 2 months ago

The user plans to switch from minoxidil to finasteride or dutasteride for hair loss, while managing hormones with aromatase inhibitors and SHBG blockers. They seek advice on the best options for these treatments, considering past side effects and future therapies.

community Attempting to assist people with gyno sides on finasteride

in Research/Science 24 upvotes 1 year ago

Finasteride can cause gynecomastia due to hormonal imbalances. Management includes consulting an endocrinologist and using aromatase inhibitors like anastrozole or supplements like DIM and zinc.

community Finasteride doubled my testosterone & estrogen

in Chat 265 upvotes 1 week ago

Finasteride increased testosterone and estrogen, stopped hair loss, and promoted regrowth. Users discussed side effects like libido changes and considered adding minoxidil and aromatase inhibitors.

community 1 year 5-ar. Blood test results

in Finasteride/Dutasteride 3 upvotes 3 months ago

The user experienced sexual side effects after starting finasteride and later switched to dutasteride, noticing hormonal changes. They are considering using P5P and possibly aromatase inhibitors to manage high prolactin and estradiol levels.

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