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GlossaryAnastrozole

medication that reduces estrogen production to treat breast cancer

Anastrozole, also known by the brand name Arimidex, is a medication primarily used to treat breast cancer in postmenopausal women. It works by inhibiting the enzyme aromatase, which reduces the production of estrogen, a hormone that can promote the growth of certain types of breast cancer.

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research Successful Virilization of a PAIS Patient with a Missense Mutation in the Ligand-Binding Domain of the Androgen Receptor Using Combined High-Dose Testosterone and Aromatase Inhibitor

April 2019 in “Journal of the Endocrine Society”

A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.

research Fulvestrant: A New Treatment Option for Advanced Breast Cancer - Tolerability Versus Existing Agents

67 citations, October 2005 in “Annals of Oncology”

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

research A Case of Familial Male-Limited Precocious Puberty with a Novel Mutation

6 citations, August 2020 in “JCRPE”

A boy with a rare form of early puberty caused by a new gene mutation responded well to treatment aimed at reducing testosterone and preserving adult height.

research Effects of Testosterone on the Expression of Connexin 26 and Connexin 43 in the Uterus of Rats During Early Pregnancy

5 citations, January 2020 in “in Vivo”

Testosterone changes important cell communication proteins in pregnant rats' uteruses, which might affect pregnancy success.

research Daily Subcutaneous Testosterone for Management of Testosterone Deficiency

3 citations, January 2018 in “Frontiers in bioscience”

Daily subcutaneous testosterone effectively restores testosterone levels in men.

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community Gyno & testoterone level

in Finasteride 282 upvotes 8 months ago

Switching from finasteride to dutasteride and back to finasteride led to gynecomastia and fatigue, likely due to hormonal imbalances. Suggested treatments include Tamoxifen, Raloxifene, or low-dose Anastrozole, with a recommendation to test testosterone and estradiol levels.

community will long term 5ar inhibition alter my physical appearance?

in Treatment 2 upvotes 6 months ago

A 19-year-old concerned about long-term effects of 5AR inhibitors on physical appearance. They have used finasteride and plan to try dutasteride or RU58841; responses suggest improved skin, hair, and confidence.

community What happened to topical dutasteride??

in Finasteride/Dutasteride 28 upvotes 3 weeks ago

Topical dutasteride is considered for hair loss, but concerns about systemic absorption and side effects like reduced libido are common. Users have mixed results, with some preferring oral finasteride or dutasteride despite side effects, while others find topical treatments beneficial but challenging.

community 3 month into 2.5mg dutasteride - no hairs fall out of my head anymore

in Technology 37 upvotes 4 months ago

OP reports that after 3 months on 2.5mg dutasteride, their hair has stopped falling out and is thick again, but they are considering stopping due to potential mood and energy side effects. Other users discuss experiences with finasteride, dutasteride, and side effects, with some suggesting lower doses or alternative treatments like topical applications.

community Gained weight on fin but Estradiol is in normal range?

in Finasteride/Dutasteride 1 upvotes 6 months ago

A user gained 10-12 kg after starting finasteride but found their estrogen levels to be within the normal range. They are concerned about potential gynecomastia but are reassured by their lab results.

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