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GlossaryAnastrozole

medication that reduces estrogen production to treat breast cancer

Anastrozole, also known by the brand name Arimidex, is a medication primarily used to treat breast cancer in postmenopausal women. It works by inhibiting the enzyme aromatase, which reduces the production of estrogen, a hormone that can promote the growth of certain types of breast cancer.

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research Successful Virilization of a PAIS Patient with a Missense Mutation in the Ligand-Binding Domain of the Androgen Receptor Using Combined High-Dose Testosterone and Aromatase Inhibitor

April 2019 in “Journal of the Endocrine Society”

A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.

research Fulvestrant: A New Treatment Option for Advanced Breast Cancer - Tolerability Versus Existing Agents

67 citations, October 2005 in “Annals of Oncology”

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

research A Case of Familial Male-Limited Precocious Puberty with a Novel Mutation

6 citations, August 2020 in “JCRPE”

A boy with a rare form of early puberty caused by a new gene mutation responded well to treatment aimed at reducing testosterone and preserving adult height.

research Effects of Testosterone on the Expression of Connexin 26 and Connexin 43 in the Uterus of Rats During Early Pregnancy

5 citations, January 2020 in “in Vivo”

Testosterone changes important cell communication proteins in pregnant rats' uteruses, which might affect pregnancy success.

research Daily Subcutaneous Testosterone for Management of Testosterone Deficiency

3 citations, January 2018 in “Frontiers in bioscience”

Daily subcutaneous testosterone effectively restores testosterone levels in men.

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community Attempting to assist people with gyno sides on finasteride

in Research/Science 24 upvotes 9 months ago

Finasteride can cause gynecomastia due to hormonal imbalances. Management includes consulting an endocrinologist and using aromatase inhibitors like anastrozole or supplements like DIM and zinc.

community Gyno & testoterone level

in Finasteride 282 upvotes 1 year ago

Switching from finasteride to dutasteride and back to finasteride led to gynecomastia and fatigue, likely due to hormonal imbalances. Suggested treatments include Tamoxifen, Raloxifene, or low-dose Anastrozole, with a recommendation to test testosterone and estradiol levels.

community spironolactone pills to topical

in Research/Science 6 upvotes 1 month ago

Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

community Results of topical minoxidil 3 months

in Progress Pictures 66 upvotes 3 months ago

The user experienced significant hair regrowth using topical minoxidil but faced issues with gynecomastia when using oral minoxidil and finasteride. They plan to have surgery for gynecomastia and consider using finasteride again, while questioning if minoxidil alone can maintain hair growth.

community will long term 5ar inhibition alter my physical appearance?

in Treatment 2 upvotes 10 months ago

A 19-year-old concerned about long-term effects of 5AR inhibitors on physical appearance. They have used finasteride and plan to try dutasteride or RU58841; responses suggest improved skin, hair, and confidence.

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