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    Glossary Aromatase Inhibitors

    block estrogen production by inhibiting the aromatase enzyme

    Aromatase Inhibitors (AIs) are a class of drugs that block the enzyme aromatase, which is responsible for converting androgens into estrogens. By reducing estrogen levels, AIs are commonly used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women, as estrogen can promote the growth of certain types of breast cancer cells.

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    1. Management of Sexual Dysfunction in Postmenopausal Breast Cancer Patients Taking Adjuvant Aromatase Inhibitor Therapy Current Oncology · 2007 · 90 citations
    2. Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: A possible androgenic bone protective effects induced by exemestane Bone · 2006 · 50 citations
    3. Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor The Journal of Steroid Biochemistry and Molecular Biology · 2005 · 44 citations
    4. Intravaginal Testosterone Improves Sexual Satisfaction and Vaginal Symptoms Associated With Aromatase Inhibitors The Journal of Clinical Endocrinology and Metabolism · 2018 · 37 citations
    5. Aromatase inhibitor therapy and hair loss among breast cancer survivors Breast Cancer Research and Treatment · 2013 · 34 citations
    6. Aromatase inhibitors induce ‘male pattern hair loss’ in women? Annals of Oncology · 2013 · 19 citations
    7. Reduced estradiol synthesis by letrozole, an aromatase inhibitor, is protective against development of pentylenetetrazole-induced kindling in mice Neurochemistry International · 2015 · 14 citations
    8. Art of prevention: The importance of dermatologic care when using aromatase inhibitors International Journal of Women’s Dermatology · 2021 · 10 citations
    9. A Phase II Study of Vaginal Testosterone Cream (TEST) vs. Estring for Vaginal Dryness or Decreased Libido in Women with Early Stage Breast Cancer (BC) Treated with Aromatase Inhibitors (AIs). Cancer Research · 2009 · 9 citations
    10. Evaluation of dermatologic adverse events associated with aromatase inhibitors: insights from the FAERS database Frontiers in Pharmacology · 2025 · 2 citations
    11. Adverse events associated with aromatase inhibitors: an analysis of real-world datasets and drug-gene interaction network Expert Opinion on Drug Safety · 2024 · 1 citations
    12. Aromatase inhibitor–induced hair loss in two adolescents Pediatric Dermatology · 2020 · 1 citations
    13. Design, synthesis and structure-activity relationships studies on steroidal aromatase and 5α-reductase inhibitors as anti-tumors Estudo Geral (Universidade de Coimbra) · 2013
    14. SAT-288 Successful Virilization of a PAIS Patient with a Missense Mutation In The Ligand-binding Domain Of The Androgen Receptor with Combined High-dose Testosterone and Aromatase Inhibitor Journal of the Endocrine Society · 2019
    15. A case of aromatase inhibitor‐induced alopecia successfully treated with low‐dose oral minoxidil Journal of Cosmetic Dermatology · 2023
    16. CDK4/6 plus aromatase inhibitor-induced alopecia in breast cancer patients. Journal of Clinical Oncology · 2019 · 4 citations
    17. The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog <i>Silurana tropicalis</i> Sexual Development · 2009 · 37 citations
    18. Amiodarone-Induced Toxic Epidermal Necrolysis; Nilotinib-Associated Cerebrovascular Disease and Stroke; Pisa Syndrome Caused by Paliperidone; Macroglossia Associated with Methylprednisolone; Aromatase Inhibitor-Induced “Male Pattern Baldness” in Women? Acute Liver Failure Due to Etodolac Hospital Pharmacy · 2013
    19. The Safety of Local Hormonal Treatment for Vulvovaginal Atrophy in Women With Estrogen Receptor-positive Breast Cancer Who Are on Adjuvant Aromatase Inhibitor Therapy: Meta-analysis Clinical breast cancer · 2019 · 18 citations
    20. Sex steroid synthesis in human skin in situ: The roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin Molecular and Cellular Endocrinology · 2012 · 46 citations
    21. Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice Epilepsy research · 2018 · 11 citations
    22. Treatment options for polycystic ovary syndrome International journal of women's health · 2011 · 514 citations
    23. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol Neuroscience · 2004 · 136 citations
    24. Health and fertility in World Health Organization group 2 anovulatory women Human Reproduction Update · 2012 · 88 citations
    25. Endocrine Therapy–Induced Alopecia in Patients With Breast Cancer JAMA Dermatology · 2018 · 67 citations
    26. Androgens and ovarian function: translation from basic discovery research to clinical impact Journal of Endocrinology · 2019 · 55 citations
    27. Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia JAMA Dermatology · 2019 · 43 citations
    28. Polycystic ovary syndrome (PCOS) Annales D Endocrinologie · 2010 · 40 citations
    29. Polycystic ovary syndrome and infertility: an update International journal of adolescent medicine and health · 2021 · 26 citations
    30. Bee pollen and honey for the alleviation of hot flushes and other menopausal symptoms in breast cancer patients Molecular and clinical oncology · 2015 · 24 citations