Reduced Estradiol Synthesis by Letrozole, an Aromatase Inhibitor, Is Protective Against Development of Pentylenetetrazole-Induced Kindling in Mice

    October 2015 in “ Neurochemistry International
    Davood Rashid, Bibhu Prasad Panda, Divya Vohora
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    Studysummary This study found that letrozole, an aromatase inhibitor, reduced the incidence and severity of PTZ-induced kindling seizures in mice, potentially due to its effects on 17β-estradiol and neurosteroid synthesis.
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