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GlossaryAromatase Inhibitors

block estrogen production by inhibiting the aromatase enzyme

Aromatase Inhibitors (AIs) are a class of drugs that block the enzyme aromatase, which is responsible for converting androgens into estrogens. By reducing estrogen levels, AIs are commonly used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women, as estrogen can promote the growth of certain types of breast cancer cells.

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research Management of Sexual Dysfunction in Postmenopausal Breast Cancer Patients Taking Adjuvant Aromatase Inhibitor Therapy

90 citations , December 2007 in “Current Oncology”

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

research Effects of Aromatase Inhibitors on Human Osteoblast and Osteoblast-Like Cells: A Possible Androgenic Bone Protective Effect Induced by Exemestane

50 citations , December 2006 in “Bone”

Exemestane may protect bones by stimulating osteoblast growth through androgen-related pathways.

research Aromatase-Independent Testosterone Conversion Into Estrogenic Steroids Is Inhibited by a 5α-Reductase Inhibitor

44 citations , December 2005 in “The Journal of Steroid Biochemistry and Molecular Biology”

Combining 5α-reductase and aromatase inhibitors may better reduce estrogen levels.

The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

research The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

37 citations , January 2009 in “Sexual Development”

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

research Intravaginal Testosterone Improves Sexual Satisfaction and Vaginal Symptoms Associated With Aromatase Inhibitors

37 citations , September 2018 in “The Journal of Clinical Endocrinology and Metabolism”

Intravaginal testosterone cream improves sexual satisfaction and reduces vaginal discomfort in postmenopausal women on breast cancer treatment without affecting hormone levels.

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community Can aromatase inhibitors make dutasteride/finasteride useless?

in Finasteride/Dutasteride 9 upvotes 1 year ago

The conversation discusses using aromatase inhibitors with dutasteride or finasteride for hair loss, which can prevent testosterone from turning into estrogen but may lead to increased DHT and potentially make finasteride less effective. There's concern about proper dosing and side effects like gynecomastia and emotional changes.

community Hormone Management Advice - Aromatase Inhibitors , SHBG Blockers

in Finasteride/Dutasteride 3 upvotes 3 months ago

The user plans to switch from minoxidil to finasteride or dutasteride for hair loss, while managing hormones with aromatase inhibitors and SHBG blockers. They seek advice on the best options for these treatments, considering past side effects and future therapies.

community Attempting to assist people with gyno sides on finasteride

in Research/Science 25 upvotes 1 year ago

Finasteride can cause gynecomastia due to hormonal imbalances. Management includes consulting an endocrinologist and using aromatase inhibitors like anastrozole or supplements like DIM and zinc.

community Finasteride doubled my testosterone & estrogen

in Chat 265 upvotes 3 weeks ago

Finasteride increased testosterone and estrogen, stopped hair loss, and promoted regrowth. Users discussed side effects like libido changes and considered adding minoxidil and aromatase inhibitors.

community How long would dermarolling and minoxidil work for if you can’t use finasteride? 24m mild diffuse thinning up to crown

in Treatment 9 upvotes 4 years ago

Long-term efficacy of dermarolling with minoxidil is discussed for hair loss treatment. User can't use RU, Fin, or topical Fin due to side effects and considers using finasteride with an aromatase inhibitor as a last resort.

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