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GlossaryAromatase Inhibitors

block estrogen production by inhibiting the aromatase enzyme

Aromatase Inhibitors (AIs) are a class of drugs that block the enzyme aromatase, which is responsible for converting androgens into estrogens. By reducing estrogen levels, AIs are commonly used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women, as estrogen can promote the growth of certain types of breast cancer cells.

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research Management of Sexual Dysfunction in Postmenopausal Breast Cancer Patients Taking Adjuvant Aromatase Inhibitor Therapy

90 citations, December 2007 in “Current Oncology”

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

research The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

37 citations, January 2009 in “Sexual Development”

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

research Intravaginal Testosterone Improves Sexual Satisfaction and Vaginal Symptoms Associated With Aromatase Inhibitors

37 citations, September 2018 in “The Journal of Clinical Endocrinology and Metabolism”

Intravaginal testosterone cream improves sexual satisfaction and reduces vaginal discomfort in postmenopausal women on breast cancer treatment without affecting hormone levels.

research Aromatase Inhibitor Therapy and Hair Loss Among Breast Cancer Survivors

34 citations, November 2013 in “Breast Cancer Research and Treatment”

Aromatase inhibitor therapy for breast cancer increases the risk of hair loss and thinning.

research Aromatase Inhibitors Induce Male Pattern Hair Loss in Women

19 citations, May 2013 in “Annals of Oncology”

Aromatase inhibitors cause male pattern hair loss in women.

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community Can aromatase inhibitors make dutasteride/finasteride useless?

in Finasteride/Dutasteride 9 upvotes 7 months ago

The conversation discusses using aromatase inhibitors with dutasteride or finasteride for hair loss, which can prevent testosterone from turning into estrogen but may lead to increased DHT and potentially make finasteride less effective. There's concern about proper dosing and side effects like gynecomastia and emotional changes.

community How long would dermarolling and minoxidil work for if you can’t use finasteride? 24m mild diffuse thinning up to crown

in Treatment 7 upvotes 3 years ago

Long-term efficacy of dermarolling with minoxidil is discussed for hair loss treatment. User can't use RU, Fin, or topical Fin due to side effects and considers using finasteride with an aromatase inhibitor as a last resort.

community After almost 4 months on fin, it looks like I might be unlucky enough to develop early sings of gyno...

in Finasteride/Dutasteride 6 upvotes 4 years ago

After nearly four months on finasteride, a user noticed improved hair quality but developed nipple puffiness, suggesting early signs of gynecomastia. They considered switching to other treatments like CB-03-01 or RU58841 and contemplated consulting an endocrinologist about aromatase inhibitors.

community 1 year later, min 2ml daily, fin 1mg to 0.5 daily + microneedling

in Finasteride/Dutasteride 147 upvotes 1 year ago

The user, Salt_Ad6339, shares their positive experience with hair regrowth after using minoxidil and finasteride for a year, along with microneedling. However, they also mention experiencing chest/nipple pain and suspect it may be a side effect of finasteride. They decide to stop using it for now and see if minoxidil alone can maintain their hair. Other users in the conversation discuss the potential side effects of finasteride and suggest using an aromatase inhibitor to counteract them.

community Estrogen lowering supplements while on Finasteride?

in Treatment 7 upvotes 2 years ago

The conversation discusses using aromatase inhibiting supplements like DIM and Grape Seed extract while on finasteride for hair loss treatment. Users share their experiences and opinions on combining these supplements with finasteride.

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