TLDR Combining 5α-reductase and aromatase inhibitors may better reduce estrogen levels.
The study demonstrated that testosterone could be converted into estrogenic steroids independently of aromatase in both HeLa and MCF-7 cells. This conversion was inhibited by the 5α-reductase inhibitor finasteride, suggesting that these estrogenic steroids are generated downstream of dihydrotestosterone. The findings indicated that combining a 5α-reductase inhibitor with an aromatase inhibitor might more effectively reduce estrogenic steroids in vivo than using an aromatase inhibitor alone. This research provided insights into potential treatments for estrogen-dependent tumors by targeting both aromatase-dependent and independent pathways.
1707 citations
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December 2003 in “The New England Journal of Medicine” Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.
56 citations
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December 2002 in “The Journal of Clinical Endocrinology & Metabolism” Human bone cells mainly produce a type 1 enzyme that may help regulate bone health.
237 citations
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December 2001 in “Urology” Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.
72 citations
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January 2011 in “Current Pharmaceutical Design” S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
30 citations
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December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.
18 citations
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June 2009 in “Journal of Molecular Endocrinology” Finasteride exposure harms tadpole reproduction and hormone balance.
31 citations
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September 2008 in “International Journal of Andrology” 5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.
6 citations
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September 2012 in “Clinical Interventions in Aging” Honokiol might help reduce male skin aging by maintaining testosterone levels.
