Aromatase-Independent Testosterone Conversion Into Estrogenic Steroids Is Inhibited by a 5α-Reductase Inhibitor

    December 2005 in “ The Journal of Steroid Biochemistry and Molecular Biology ”
    Toshio Ishikawa, Christine Glidewell-Kenney, J. Larry Jameson
    Studysummary This study found that testosterone is converted to estrogenic steroids in vitro without aromatase involvement, suggesting that combining 5α-reductase and aromatase inhibitors might reduce estrogenic steroids more completely in vivo.
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    Research cited in this study 3

    1. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003
    2. Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1 The Journal of Clinical Endocrinology & Metabolism · 2002
    3. 5α-Reductase Activity in the Prostate Urology · 2001