5 Alpha-Reductase Inhibitors

February 2020 in “ Definitions ”

이신영, 하문수, 응웬 하이박, 이주형, 이장희, 명순철, 김세철

5 Alpha-Reductase Inhibitors steroid 5-alpha-reductase testosterone dihydrotestosterone DHT androgen receptors androgenic effects

TLDR 5 Alpha-Reductase Inhibitors reduce the effects of testosterone by blocking its conversion into a stronger form.

The document from February 6, 2020, discussed 5 Alpha-Reductase Inhibitors, substances that inhibit the enzyme steroid 5-alpha-reductase. This enzyme is responsible for converting testosterone into dihydrotestosterone (DHT), which has three times greater affinity for androgen receptors than testosterone. Therefore, inhibiting 5-alpha-reductase results in a significant reduction in the androgenic effects of testosterone.

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The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

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research 5 Alpha-Reductase Inhibitors: What's New?

47 citations, January 2003 in “Current opinion in urology”

A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.