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    Setipiprant

    Setipiprant (INN; developmental code names ACT-129968, KYTH-105) is an investigational drug developed for the treatment of asthma and scalp hair loss. It was originally developed by Actelion and acts as a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2). The drug is being developed as a novel treatment for male pattern baldness by Allergan.

    Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

    Research 8

    1. Does Inhibition of Aldose Reductase Contribute to the Anti-Inflammatory Action of Setipiprant? Physiological Research · 2017 · 6 citations
    2. Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1<i>H</i>-pyrido[4,3-<i>b</i>]indol-5(2<i>H</i>)-yl)acetic Acid (Setipiprant/ACT-129968) Journal of Medicinal Chemistry · 2015 · 6 citations
    3. Setipiprant for Androgenetic Alopecia in Males: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 2a Trial Clinical, Cosmetic and Investigational Dermatology · 2021 · 3 citations
    4. A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth Experimental Dermatology · 2018 · 30 citations
    5. New drugs under investigation for the treatment of alopecias Expert Opinion on Investigational Drugs · 2019 · 26 citations
    6. The state‐of‐the‐art in the management of androgenetic alopecia: A review of new therapies and treatment algorithms JEADV Clinical Practice · 2022 · 1 citations
    7. Topical Prostaglandin Analogues in Androgenetic Alopecia: A Systematic Review of Clinical Evidence International Journal of Drug Delivery Technology · 2026
    8. The physiological and pharmacological roles of prostaglandins in hair growth The Korean Journal of Physiology and Pharmacology · 2022
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    Community 10

    1. Best, possible, or experimental growth agonists that AREN'T MINOXIDIL. Reddit · 31 Dec 2020
    2. Thinking about signing up for the setipiprant clinical trials Reddit · 14 Jun 2017
    3. Where to buy setipiprant from ? Reddit · 11 Dec 2024
    4. Setipiprant/PGE2 feedbacks? Reddit · 10 May 2018
    5. Temple revival. Dropping Oral min. Reddit · 5 Jul 2025
    6. Gartanin Degrades dht receptor found in mangosteen fruit. Gonna buy the raw powder mix it with castor oil and filter out the rest. And apply topically. Reddit · 27 May 2018
    7. So what is the most compelling current research on a cure? Reddit · 1 Aug 2015
    8. In theory, will everyone on setipiprant be able to maintain their hair forever? Reddit · 17 Mar 2016
    9. Updates on setipiprant, bimatoprost? Reddit · 22 Sept 2015
    10. VDPHL-01 is Overrated and Ridiculous. This is just Oral Minoxidil. Reddit · 9 Feb 2025
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