Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation

December 2002 in “ Development ”

Liang Ma, Jian Liu, Tobey Wu, Maksim V. Plikus, Ting‐Xin Jiang, Qun Bi, Yi‐Hsin Liu, Sven Müller‐Röver, Heiko Peters, John P. Sundberg, Rob Maxson, Richard L. Maas, Cheng‐Ming Chuong

cyclic alopecia Msx2 hair cycling hair shaft differentiation anagen phase catagen phase telogen phase Bmp4 Bmp2 Foxn1 acidic hair keratin exogen phase

Studysummary In this study, Msx2-deficient mice showed progressive hair loss due to shortened anagen phase and prolonged catagen and telogen phases, resulting in cyclic alopecia with structurally abnormal hair shafts.

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