Sequence and Expression of Murine Type I Hair Keratins mHa2 and mHa3

    June 1994 in “ Experimental Cell Research ”
    Hermelita Winter, Petra Siry, Edda Tobiasch, Jürgen Schweizer
    TLDR mHa2 and mHa3 keratins have different structures and roles in mouse hair and tongue tissues.
    The study focused on the sequence and expression of murine type I hair keratins, specifically mHa2 and mHa3, using a cDNA library from mouse tail epidermis. It identified structural heterogeneity within the type I hair keratin subfamily, with mHa2 being distinct from mHa1, mHa3, and mHa4, particularly in its non-α-helical domains. mHa3 was expressed in cortex cells and the central unit of murine lingual filiform papillae, while mHa2 expression was restricted to the cuticle of the hair shaft. These findings suggested that the structural differences among these keratins were functionally significant in the development of hard α-keratin-expressing tissues.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Losing ground after 14 months of fin use and 11 months of min

      in Finasteride/Dutasteride  53 upvotes 3 years ago
      A 24-year-old person who is worried about their hair loss after 14 months of taking finasteride and 11 months of minoxidil. Replies to the post suggested sticking with their current regimen, that shedding from one part may not be telogen effluvium, and that shedding is normal with these drugs and they should evaluate in two to three months.

      community Hairloss has destroyed my Life completely

      in Chat  339 upvotes 8 months ago
      A young person is distressed about rapid hair loss despite using finasteride and recently starting oral minoxidil. Many suggest continuing treatment, considering dutasteride, and seeking therapy for mental health support.

      community Finasteride doubled my testosterone & estrogen

      in Chat  265 upvotes 4 months ago
      Finasteride increased testosterone and estrogen, stopped hair loss, and promoted regrowth. Users discussed side effects like libido changes and considered adding minoxidil and aromatase inhibitors.

      community The truth about Dutasteride (w/ sources)

      in Finasteride/Dutasteride  52 upvotes 3 years ago
      The effectiveness of Dutasteride compared to Finasteride in treating hair loss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.

      community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

      in Treatment  8 upvotes 5 years ago
      Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

    Similar Research

    5 / 1000+ results