The Hair Loss Encyclopedia

Structure and Site of Expression of a Murine Type II Hair Keratin

February 1992 in “ Molecular Biology Reports ”

Edda Tobiasch, J�rgen Schweizer, Hermelita Winter

TLDR A specific type II hair keratin was identified and found in hair cortex and tongue cells.

The study identified a 1770 bp-long cDNA encoding a murine type II keratin, which was distinct from epithelial keratins and suggested to be a type II hair keratin due to its structural features and amino acid composition. In situ hybridization confirmed the expression of this keratin in the upper cells of the hair cortex and suprabasal cells of the tongue's filiform papillae. The keratin had a molecular weight of 58 kD, but it was unclear if it corresponded to MHb 3 or MHb 4.

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Research cited in this study

8 / 8 results

research Differential Expression of Type I Hair Keratins

51 citations , March 1990 in “Journal of Investigative Dermatology”

research Expression of hair-related keratins in a soft epithelium: Subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation

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Hoxc13 is important for hair and tongue development by controlling hair keratin genes.

research Cloning and Characterization of a Mouse Type I Hair Keratin cDNA

41 citations , December 1988 in “Journal of Investigative Dermatology”

research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum)

187 citations , May 1988 in “Differentiation”

research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles

248 citations , April 1988 in “Differentiation”

Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.

research Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues.

57 citations , January 1987 in “Journal of Biological Chemistry”

Different keratins have unique expression patterns in mouse skin cells.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

research The complement of native α-keratin polypeptides of hair-forming cells: A subset of eight polypeptides that differ from epithelial cytokeratins

198 citations , October 1986 in “Differentiation”

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research Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins.

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