Structure and Site of Expression of a Murine Type II Hair Keratin

February 1992 in “ Molecular Biology Reports ”

Edda Tobiasch, J�rgen Schweizer, Hermelita Winter

type II hair keratin cDNA in situ hybridization hair cortex suprabasal cells filiform papillae amino acid composition

Studysummary This study identified and characterized a murine type II hair keratin, demonstrating its presence in specific cells of hair and tongue tissues.

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The study identified a 1770 bp-long cDNA encoding a murine type II keratin, which was distinct from epithelial keratins and suggested to be a type II hair keratin due to its structural features and amino acid composition. In situ hybridization confirmed the expression of this keratin in the upper cells of the hair cortex and suprabasal cells of the tongue's filiform papillae. The keratin had a molecular weight of 58 kD, but it was unclear if it corresponded to MHb 3 or MHb 4.

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