Hybrid Hair Follicle Stem Cell Extracellular Vesicles Co-Delivering Finasteride and Gold Nanoparticles for Androgenetic Alopecia Treatment

    August 2024 in “ Journal of Controlled Release
    Xiaochuan Wu, Xixi Huang, Qi Zhu, Jucong Zhang, Jiahao Hu, Yanling Song, Yuchan You, Luwen Zhu, Jingyi Lu, Xinyi Xu, Minjiang Chen, Wei Wang, Xiuzu Song, Jiansong Ji, Yongzhong Du
    TLDR A new treatment using hybrid vesicles with gold nanoparticles and finasteride significantly improves hair regrowth for androgenetic alopecia.
    The study explores a novel treatment for androgenetic alopecia (AGA) using hybrid hair follicle stem cell extracellular vesicles (EVs) co-delivering finasteride and gold nanoparticles (AuNPs). This approach aims to enhance therapeutic efficacy and safety by improving drug encapsulation efficiency, storage stability, and follicle retention. The encapsulation efficiency (EE%) of finasteride reached 45.33%, and the hybrid vesicles showed no significant cytotoxicity in human-derived dermal papilla cells (HDPCs) and human umbilical vein endothelial cells (HUVECs) in vitro. The treatment also facilitated dermal papilla cell migration and hair follicle retention, suggesting it as a promising clinical option for AGA with minimal side effects.
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