Hybrid Hair Follicle Stem Cell Extracellular Vesicles Co-Delivering Finasteride and Gold Nanoparticles for Androgenetic Alopecia Treatment

    August 2024 in “ Journal of Controlled Release
    Xiaochuan Wu, Xixi Huang, Qi Zhu, Jucong Zhang, Jiahao Hu, Yanling Song, Yuchan You, Luwen Zhu, Jingyi Lu, Xinyi Xu, Minjiang Chen, Wei Wang, Xiuzu Song, Jiansong Ji, Yongzhong Du
    TLDR A new treatment using hybrid vesicles with gold nanoparticles and finasteride significantly improves hair regrowth for androgenetic alopecia.
    The study explores a novel treatment for androgenetic alopecia (AGA) using hybrid hair follicle stem cell extracellular vesicles (EVs) co-delivering finasteride and gold nanoparticles (AuNPs). This approach aims to enhance therapeutic efficacy and safety by improving drug encapsulation efficiency, storage stability, and follicle retention. The encapsulation efficiency (EE%) of finasteride reached 45.33%, and the hybrid vesicles showed no significant cytotoxicity in human-derived dermal papilla cells (HDPCs) and human umbilical vein endothelial cells (HUVECs) in vitro. The treatment also facilitated dermal papilla cell migration and hair follicle retention, suggesting it as a promising clinical option for AGA with minimal side effects.
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      community 10 months fin 1mg - not much if any progress :/

      in Progress Pictures  80 upvotes 1 week ago
      The user has been using finasteride for 10 months with no significant regrowth but no further hair loss and is considering adding oral minoxidil despite concerns about side effects. Other users suggest combining finasteride with minoxidil for better results, as finasteride prevents further hair loss while minoxidil aids regrowth.

      community 3 months on fin, hopeful progress

      in Progress Pictures  117 upvotes 10 months ago
      A user has seen hopeful hair regrowth after 3 months on 1mg finasteride and 0.5mm dermarolling, in addition to using minoxidil 5% for over a year. They noticed improvement in their hairline and a bald spot.

      community 28M Hair Transplant in India, will update with results.

      in Transplants  211 upvotes 10 months ago
      A 28-year-old man had a hair transplant in India, choosing not to start finasteride due to past side effects with other medications but will use minoxidil for six months post-surgery. He researched and selected a clinic in Mumbai with a high reputation, underwent a 9-hour procedure for $965, and is optimistic about the results.

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