Minoxidil Nanoparticles Targeting Hair Follicles Enhance Hair Growth in C57BL/6 Mice

    April 2022 in “ Pharmaceutics ”
    Yoshihiro Oaku, Akinari Abe, Yohei Sasano … Noriaki Nagai
    Studysummary This study reported that 5% minoxidil nanoparticles enhanced hair growth more effectively in mice than a commercial minoxidil solution, with significantly higher drug accumulation in the upper hair follicles.
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    Research cited in this study 31

    1. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    2. Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia European Journal of Pharmaceutics and Biopharmaceutics · 2022
    3. Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles, and Dermal Papilla Cells Clinical, Cosmetic and Investigational Dermatology · 2021
    4. A Systematic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia Natural Products and Bioprospecting · 2020
    5. Developing Formulations for Drug Follicular Targeting: Nanoemulsions Loaded with Minoxidil and Clove Oil Journal of drug delivery science and technology · 2020
    6. Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia Cosmetics · 2020
    7. Clinical Efficacy of a Topical Compounded Formulation in Male Androgenetic Alopecia: Minoxidil 10%, Finasteride 0.1%, Biotin 0.2%, and Caffeine Citrate 0.05% Hydroalcoholic Solution PubMed · 2020
    8. Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice International Journal of Nanomedicine · 2019
    9. Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation Journal of Dermatological Treatment · 2019
    10. Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery Medicines · 2018
    11. Minoxidil-Encapsulated Poly(L-Lactide-Co-Glycolide) Nanoparticles with Hair Follicle Delivery Properties Prepared Using Solvent Evaporation and Sonication Bio-medical Materials and Engineering · 2018
    12. Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting Pharmaceutics · 2018
    13. Preparation and In Vivo Evaluation of Lecithin-Based Microparticles for Topical Delivery of Minoxidil Archives of Pharmacal Research · 2017
    14. Comparison of Saccharina Japonica–Undaria Pinnatifida Mixture and Minoxidil on Hair Growth Promoting Effect in Mice Archives of Plastic Surgery · 2016
    15. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    16. Iontophoresis of Minoxidil Sulphate Loaded Microparticles: A Strategy for Follicular Drug Targeting? Colloids and Surfaces B: Biointerfaces · 2015
    17. Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells Nanomedicine: Nanotechnology, Biology and Medicine · 2015
    18. Visible-To-Near IR Quantum Dot-Based Hypermulticolor High-Content Screening of Herbal Medicines for Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition SLAS discovery · 2012
    19. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men Journal der Deutschen Dermatologischen Gesellschaft · 2011
    20. Solid Lipid Nanoparticles Suspension Versus Commercial Solutions for Dermal Delivery of Minoxidil International Journal of Pharmaceutics · 2011
    21. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    22. Randomized Clinical Trial Comparing 5% and 1% Topical Minoxidil for the Treatment of Androgenetic Alopecia in Japanese Men Journal of Dermatology · 2009
    23. Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil International Journal of Pharmaceutics · 2009
    24. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of controlled release · 2004
    25. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of Controlled Release · 2004
    26. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    27. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003
    28. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    29. The Hair Growing Effect of Minoxidil Annals of the New York Academy of Sciences · 1991
    30. Action of Topical Minoxidil in the Bald Stump-Tailed Macaque Journal of The American Academy of Dermatology · 1987
    31. The Stumptailed Macaque as a Model for Baldness: Effects of Minoxidil International Journal of Cosmetic Science · 1986

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    1. Hair Loss (Alopecia or Baldness) 2018
    2. Treatments of Hereditary Hair Loss (Alopecia) 2018
    3. Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells Journal of clinical & experimental dermatology research · 2014
    4. Fullerene Nanomaterials Potentiate Hair Growth Nanomedicine · 2009
    5. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001