Minoxidil Nanoparticles Targeting Hair Follicles Enhance Hair Growth in C57BL/6 Mice

    April 2022 in “ Pharmaceutics
    Yoshihiro Oaku, Akinari Abe, Yohei Sasano, Fuka Sasaki, Chika Kubota, Naoki Yamamoto, Tohru Nagahama, Noriaki Nagai
    TLDR Minoxidil nanoparticles significantly boost hair growth in mice compared to regular minoxidil.
    The study demonstrated that a 5% minoxidil nanoparticle (MXD-NPs) formulation significantly enhanced hair growth in C57BL/6 mice compared to conventional minoxidil solutions. MXD-NPs, with a mean particle size of 139.8 nm, delivered 7.4 times higher concentrations of minoxidil to the hair bulge, leading to increased activation of hair follicle epithelial stem cells (HFSC). This resulted in higher mRNA and protein levels of hair growth factors IGF-1 and VEGF, and noticeable hair growth effects within 8 days. The findings suggest that MXD-NPs are more effective in promoting hair growth by targeting hair follicles, offering a promising treatment for androgenetic alopecia (AGA).
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