Developing Formulations for Drug Follicular Targeting: Nanoemulsions Loaded with Minoxidil and Clove Oil

    July 2020 in “ Journal of drug delivery science and technology ”
    Stephani Araujo Cardoso, Thaís Nogueira Barradas
    Studysummary This study found that nano-sized minoxidil formulations significantly increased skin penetration and follicular drug delivery for alopecia areata treatment, compared to conventional ethanol-based solutions, and demonstrated effective controlled release over six hours.
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    Research cited in this study 19

    1. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    2. Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery Medicines · 2018
    3. Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting Pharmaceutics · 2018
    4. Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery European Journal of Pharmaceutical Sciences · 2016
    5. Squarticles as a Nanocarrier for Targeting Minoxidil to Hair Follicles and Dermal Papilla Cells Journal of Dermatological Science · 2016
    6. Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles International Journal of Biological Macromolecules · 2015
    7. Lipid Nanoparticles for Topical and Transdermal Application for Alopecia Treatment: Development, Physicochemical Characterization, and In Vitro Release and Penetration Studies International Journal of Nanomedicine · 2014
    8. New Aspects of the Treatment of Alopecia Areata Postępy Dermatologii i Alergologii · 2014
    9. Design and Evaluation of Hydrogel-Thickened Microemulsion for Topical Delivery of Minoxidil 2013
    10. Penetration of Drugs Through Skin: A Complex Rate-Controlling Membrane 2012
    11. Targeted Delivery of a Poorly Water-Soluble Compound to Hair Follicles Using Polymeric Nanoparticle Suspensions International journal of pharmaceutics · 2011
    12. Transcutol-Containing Vesicles for Topical Delivery of Minoxidil Journal of Drug Targeting · 2010
    13. Targeting to the Hair Follicles: Current Status and Potential Journal of dermatological science · 2010
    14. Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro Journal of Pharmaceutical Sciences · 2009
    15. Transfollicular Drug Delivery: Is It a Reality? International journal of pharmaceutics · 2005
    16. Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle Autoimmunity Reviews · 2005
    17. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    18. Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001
    19. Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata Journal of The American Academy of Dermatology · 1987

    Related research 3

    1. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023
    2. Topical Minoxidil for the Treatment of Alopecia Areata PubMed · 2017
    3. Effectivity of Minoxidil as a Treatment for Alopecia Areata DOAJ (DOAJ: Directory of Open Access Journals) · 2013