Design and Evaluation of Hydrogel-Thickened Microemulsion for Topical Delivery of Minoxidil

    October 2013
    Sunitha Sampathi, Jitendra Wankar, Sujatha Dodoala, Mankala Santhosh Kumar
    TLDR The new hydrogel and microemulsion could be better for hair loss treatment than current solutions.
    The study aimed to improve the topical delivery of minoxidil by developing microemulsions and microemulsion-based hydrogel systems (MEHs) to increase percutaneous penetration and reduce the need for repeated applications. Using oleic acid, Tween 80, and polyethyleneglycol 200, the researchers optimized the formulations and evaluated them for various parameters, including drug content, viscosity, pH, permeation, skin irritation, and stability. The microemulsion F4 showed sustained drug release over 24 hours and was incorporated into a hydrogel for comparison with a marketed solution. The microemulsion and MEH demonstrated controlled drug release with no dermatological reactions and were stable on storage, suggesting they could be more effective for hair loss treatment than existing solutions.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Reql minoxidil vs fake minoxidil (right)

      in Minoxidil  239 upvotes 5 days ago
      Counterfeit minoxidil is a concern, with users suggesting buying from reputable sources like Costco to ensure authenticity. A bleach test can help verify genuine minoxidil.

      community Smoking minoxidil, the theory that changes everything.

      in Minoxidil  591 upvotes 5 days ago
      A user humorously suggested smoking minoxidil in a blunt as an alternative hair growth method, sparking a satirical discussion on unconventional and unsafe ways to use minoxidil. The conversation included various suggestions like oral pills, rectal administration, and other absurd methods, with some users warning against the dangers of such practices.

      community Why don't Minoxidil regenerated hairs become terminal on the head?

      in Minoxidil  102 upvotes 5 days ago
      Minoxidil helps hair growth by increasing blood flow and prolonging the growth phase, but it doesn't address the root cause of hair loss, such as DHT sensitivity. Finasteride can help maintain some gains by blocking DHT, but stopping Minoxidil often leads to hair loss because the new hairs are dependent on it.

      community Be careful with minoxidil, even if it's just foam.

      in Minoxidil  12 upvotes 6 days ago
      Minoxidil caused side effects like chest pain and tinnitus for the user, leading them to stop using it and consider switching to finasteride with microneedling. Other users shared similar experiences with minoxidil, while some reported no issues, highlighting varied individual reactions.

      community 8 months on oral minoxidil. No sign of regrowth.

      in Minoxidil  14 upvotes 1 week ago
      The user has been taking 2mg oral minoxidil and 1mg finasteride but has seen no hair regrowth after 8 months, leading to concerns about being a non-responder. They are considering increasing the minoxidil dosage or switching to dutasteride, while also using keto shampoo and microneedling, but remain skeptical about the effectiveness of minoxidil.

    Similar Research

    5 / 1000+ results