TLDR The new hydrogel and microemulsion could be better for hair loss treatment than current solutions.
The study aimed to improve the topical delivery of minoxidil by developing microemulsions and microemulsion-based hydrogel systems (MEHs) to increase percutaneous penetration and reduce the need for repeated applications. Using oleic acid, Tween 80, and polyethyleneglycol 200, the researchers optimized the formulations and evaluated them for various parameters, including drug content, viscosity, pH, permeation, skin irritation, and stability. The microemulsion F4 showed sustained drug release over 24 hours and was incorporated into a hydrogel for comparison with a marketed solution. The microemulsion and MEH demonstrated controlled drug release with no dermatological reactions and were stable on storage, suggesting they could be more effective for hair loss treatment than existing solutions.
51 citations
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May 2010 in “Journal of Drug Targeting” Transcutol-containing vesicles improve minoxidil's skin penetration and hair growth promotion.
370 citations
,
September 1999 in “The New England Journal of Medicine” Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
48 citations
,
June 1988 in “PubMed” Minoxidil sulfate relaxes muscle by increasing potassium flow, making it a unique muscle relaxer.
2 citations
,
December 2019 in “Biomedical dermatology” Minoxidil works faster, but ketoconazole is a safer alternative for female hair loss.
1 citations
,
December 2022 in “Pharmaceutics” Finasteride-loaded microemulsions can effectively enhance skin delivery for treating hair loss.
19 citations
,
July 2020 in “Journal of drug delivery science and technology” Nanoemulsions with minoxidil and clove oil effectively target hair follicles for better alopecia treatment.
January 2023 in “Pharmaceutics” AA–TF#15 significantly promotes hair regrowth and could be an effective treatment for androgenic alopecia.
5 citations
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February 2022 in “Acta Biomaterialia” Nanomaterials can improve hair care products and treatments, including hair loss and alopecia, by enhancing stability and safety, and allowing controlled release of compounds, but their safety in cosmetics needs more understanding.