Topical Delivery of Atraric Acid Derived From Stereocaulon Japonicum With Enhanced Skin Permeation and Hair Regrowth Activity for Androgenic Alopecia

January 2023 in “ Pharmaceutics ”

Sultan Pulat, Laxman Subedi, Prashant Pandey, Suresh R Bhosle, Jae-Seoun Hur, Jung-Hyun Shim, Seung Yun Cho, Ki-Taek Kim, Hyung-Ho Ha, Hangun Kim, Jin Woo Park

atraric acid Stereocaulon japonicum androgenic alopecia topical formulation hair regrowth hair follicle length hair-regrowth proteins androgenic mouse model minoxidil finasteride skin irritation inflammation AA Rogaine Propecia

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary In this study, researchers developed a new topical atraric acid formulation, AA-TF#15, which showed a significantly higher drug penetration and increased hair regrowth in mice compared to minoxidil and finasteride treatments, suggesting its potential effectiveness for treating scalp androgenic alopecia.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study developed a topical formulation of atraric acid (AA) derived from Stereocaulon japonicum to treat androgenic alopecia by enhancing skin permeation and promoting hair regrowth. The optimized formulation (AA–TF#15) showed significant improvements in hair regrowth indicators such as hair follicle length, weight of regrowth hair, and activation of hair-regrowth proteins in an androgenic mouse model. AA–TF#15 outperformed minoxidil and finasteride, demonstrating 96.7% hair regrowth after 18 days without causing skin irritation or inflammation. The findings suggest that AA–TF#15 could be an effective alternative treatment for androgenic alopecia.

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