Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling

April 2022 in “ Research Square (Research Square) ”

Yeong Chan Ryu, You-Rin Kim, Ji-Yeon Park, Sehee Choi, Won-Ji Ryu, Geon-Uk Kim, Eunhwan Kim, Yumi Hwang, Heejene Kim, Gyoonhee Han, Soung-Hoon Lee, Kang-Yell Choi

pyruvate kinase M2 PKM2 TEPP-46 hair follicle stem cells HFSCs Wnt/β-catenin signaling KY19382 hair regeneration alopecia wound-induced hair follicle neogenesis hair stem cells Wnt signaling hair growth hair loss

TLDR Activating PKM2 and Wnt/β-catenin signaling together can potentially enhance hair growth and could be a treatment for hair loss.

The study investigated the role of pyruvate kinase M2 (PKM2), a key enzyme in glycolysis, in hair regeneration. It was found that the activation of PKM2 with TEPP-46 enhanced hair re-growth and the proliferation of hair follicle stem cells (HFSCs) in mice. PKM2 expression was increased through the up-regulation of the Wnt/β-catenin signaling pathway, which is involved in hair regeneration. Furthermore, a combined treatment with KY19382, an activator of the Wnt/β-catenin signaling, and TEPP-46 significantly enhanced hair re-growth and wound-induced hair follicle neogenesis. The results suggest that simultaneous activation of PKM2 and Wnt/β-catenin signaling could be a potential strategy for treating alopecia.

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Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/Beta-Catenin Signaling