Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium Ascalonicum L.) Extract

June 2022 in “ Plants ”

Warintorn Ruksiriwanich, Chiranan Khantham, Anurak Muangsanguan, Chuda Chittasupho, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Sarana Rose Sommano, Korawan Sringarm, Emilia Ferrer, Francisco J. Barba

TLDR Shallot extract may help with hair growth and treating hair loss.

The study explores the potential of shallot (Allium ascalonicum L.) extract for promoting hair growth and treating androgenetic alopecia (AGA). Rich in phenolic compounds like quercetin, rosmarinic, and p-coumaric acids, the extract exhibits significant anti-inflammatory properties by reducing nitric oxide production. It downregulates androgen-related genes (SRD5A1 and SRD5A2) and upregulates genes involved in hair growth pathways (CTNNB1, SHH, SMO, GIL1, and VEGF). The extract was non-cytotoxic at concentrations up to 1 mg/mL, maintaining over 80% cell viability. These findings suggest that shallot extract could be developed into nutraceutical, nutricosmetic, and cosmeceutical products for AGA treatment, although further research is needed to confirm its efficacy and safety.

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