iNOS Inhibits Hair Regeneration in Obese Diabetic (ob/ob) Mice

May 2018 in “ Biochemical and Biophysical Research Communications ”

Mari Sasaki, Shohei Shinozaki, Hitoshi Morinaga, Masao Kaneki, Emi K. Nishimura, Kentaro Shimokado

inducible nitric oxide synthase iNOS telogen phase anagen phase nitric oxide donor hair cycle obese diabetic mice ob/ob mice iNOS inhibitor hair regeneration alopecia inflammatory conditions diabetes hair growth hair loss hair cycle phases inflammation

Studysummary In this study, researchers found that inhibiting inducible nitric oxide synthase (iNOS) promoted hair growth in diabetic mice, suggesting iNOS-derived nitric oxide contributes to hair loss under diabetic inflammatory conditions. Our plain-language summary of this paper — not a Tressless recommendation.

The study from July 1, 2018, found that inducible nitric oxide synthase (iNOS) plays a role in hair loss associated with obesity and diabetes by prolonging the telogen phase of the hair cycle in obese diabetic (ob/ob) mice. By creating iNOS-deficient ob/ob mice and administering an iNOS inhibitor, the researchers observed an enhanced transition from the telogen to anagen phase, indicating that inhibition of iNOS could promote hair growth. Conversely, a nitric oxide donor extended the telogen phase in wild-type mice. The study suggests that iNOS-derived nitric oxide contributes to hair loss under inflammatory conditions seen in diabetes and that iNOS inhibitors might serve as potential treatments for alopecia. The number of mice used in the experiments ranged from four to eight per group for genetic studies and six to seven per group for inhibitor treatment studies.

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