Alopecia and the Metabolic Syndrome

September 2017 in “ Clinics in Dermatology ”

Cheryl Jia Ling Lie, Choon Fong Liew, Hazel H Oon

Studysummary This review explores the relationship between androgenetic alopecia and metabolic syndrome, suggesting an association that supports considering cardiovascular risk assessments in patients with this type of hair loss.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document from 2018 examines the link between androgenetic alopecia (AGA) and metabolic syndrome (MetS), showing a significant association, especially in men. AGA, a common hair loss form, involves androgens like dihydrotestosterone (DHT) causing follicular miniaturization. MetS comprises conditions that raise the risk of cardiovascular disease, stroke, and diabetes. Studies reviewed suggest a strong connection between AGA and MetS, as well as AGA and MetS components such as dyslipidemia, hypertension, and coronary artery disease. The document also explores AGA's relationship with other metabolic conditions like PCOS and Cushing's syndrome, advocating for MetS screening in AGA patients. It mentions a case-control study with 80 Thai men and a larger study with 7126 patients but calls for more research, particularly on women. Additionally, the document discusses the role of nutrient deficiencies in hair loss and the unclear effects of supplementation, the commonality of hair loss after bariatric surgery, and the limited evidence linking lifestyle factors to AGA. It also differentiates alopecia areata (AA) as autoimmune and not strongly linked to MetS. The conclusion suggests that AGA patients could be screened for MetS to prevent cardiovascular issues, but more studies are needed to establish definitive guidelines.

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