Hypertension and Aldosterone Levels in Women with Early-Onset Androgenetic Alopecia

November 2009 in “ British Journal of Dermatology ”

Salvador Arias-Santiago, M.T. Gutiérrez-Salmerón, Agustín Buendía-Eisman, María Sierra Girón-Prieto, Ramón Naranjo-Sintes

androgenetic alopecia hypertension aldosterone aldosterone antagonists blood pressure alopecia progression AGA BP

TLDR Women with early hair loss have higher blood pressure and aldosterone; screening and treatment may help.

This study found that women with early-onset androgenetic alopecia (AGA) have higher levels of hypertension and aldosterone, which may contribute to the development of AGA. The study recommends blood pressure screening for women with AGA to allow for earlier diagnosis and appropriate treatment. Aldosterone antagonists have been used for a long time for female AGA and may exert a dual beneficial effect in hypertensive patients with AGA, controlling BP and preventing alopecia progression, especially if taken in early stages. However, further studies are needed to confirm these findings.

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Research cited in this study

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research Elevated Aldosterone Levels in Patients with Androgenetic Alopecia

30 citations, November 2009 in “British Journal of Dermatology”

Higher aldosterone levels link to hair loss and high blood pressure.

Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations, August 2007 in “American Journal of Pathology”

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

research Androgenetic Alopecia and Coronary Artery Disease in Women

37 citations, December 2005 in “Dermatology Online Journal”

Women under 55 with hair loss (AGA) may have a higher risk of heart disease (CAD).

research Established Risk Factors for Coronary Heart Disease Are Unrelated to Androgen-Induced Baldness in Female-to-Male Transsexuals

57 citations, January 2004 in “Journal of Endocrinology”

Baldness caused by male hormones in female-to-male transsexuals doesn't increase the risk of heart disease.

research Hair Loss, Insulin Resistance, and Heredity in Middle-Aged Women: A Population-Based Study

49 citations, June 2003 in “European journal of cardiovascular prevention & rehabilitation”

Hair loss in middle-aged women is often linked to insulin resistance and a family history of hair loss, particularly from their fathers.

research Early Onset of Androgenetic Alopecia Associated With Early Severe Coronary Heart Disease: A Population-Based, Case-Control Study

56 citations, June 2001 in “European journal of cardiovascular prevention & rehabilitation”

Early balding linked to higher heart disease risk.

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