Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

    August 2007 in “ American Journal of Pathology ”
    Yannis Sainte–Marie, A. Toulon, Ralf Paus … Frédéric Jaisser
    Studysummary This study found that overexpression of the mineralocorticoid receptor in a mouse model led to premature epidermal barrier development, keratinocyte apoptosis, and postnatal alopecia, indicating new roles for MR signaling in skin physiology.
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