TLDR Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.
In this study, researchers found that mice lacking the vitamin D receptor (VDR) gene developed alopecia due to disrupted hair follicle cycling. The hair follicles of Vdr null mice deteriorated during the first catagen phase, failing to cycle normally. This disruption was linked to increased expression of the hairless (Hr) gene, a regulator of hair follicle cycling. Hr levels were higher in Vdr null mice compared to wildtype controls, suggesting that VDR is necessary for regulating Hr expression and normal hair follicle cycling. Both VDR and Hr were essential for maintaining hair follicle structure and function.
78 citations,
November 2005 in “Endocrinology” Hairless protein can block vitamin D activation in skin cells.
140 citations,
April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.
57 citations,
April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Vitamin D receptor is crucial for starting hair growth after birth.
854 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
180 citations,
January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Vitamin D Receptor is crucial for normal skin and hair growth.
139 citations,
September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.
54 citations,
May 2001 in “Journal of Investigative Dermatology” 20 citations,
April 2000 in “Experimental dermatology” ODC transgenic mice can model human hair loss with skin lesions.
126 citations,
October 1998 in “Experimental Dermatology” 71 citations,
May 1996 in “Journal of Investigative Dermatology”
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific mutation in the TRPV3 gene causes hair follicle cells to develop improperly, leading to hair loss.
45 citations,
April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
94 citations,
February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
