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Glossary Hairless Gene

gene regulating hair growth, mutations cause permanent hair loss

The Hairless Gene, often abbreviated as HR gene, is a gene that plays a crucial role in the regulation of hair growth and development. Mutations in this gene can lead to conditions such as congenital atrichia, where individuals are born with hair that is subsequently lost and not regrown, resulting in permanent hairlessness. This gene is essential for the normal cycling of hair follicles and the maintenance of hair.

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Research

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research The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

178 citations , October 2001 in “Genes & Development”

This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.

research The Role of the Hairless (hr) Gene in the. Regulation of Hair Follicle Catagen Transformation

166 citations , July 1999 in “American Journal Of Pathology”

This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

139 citations , September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

This case report describes a patient with mutations in both alleles of the vitamin D receptor who exhibited hair loss clinically indistinguishable from generalized atrichia with papules, suggesting a potential genetic pathway shared with the hairless gene.

research Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans

126 citations , October 1998 in “Experimental Dermatology”

This review provides an overview of the hairless gene in mice and humans, discussing its structure, expression, and implications for understanding skin physiology and human disorders related to gene disruption, but it reports no new empirical findings.

research A Missense Mutation in the Zinc-Finger Domain of the Human Hairless Gene Underlies Congenital Atrichia in a Family of Irish Travellers

83 citations , October 1998 in “The American Journal of Human Genetics”

A specific gene mutation causes complete hair loss in an Irish Traveller family.

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Community Join

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community Hairloss Treatment - General health and efficacy-conscious stack overview

1 year ago

The conversation discusses managing hair loss and seborrheic dermatitis with treatments like minoxidil, finasteride, and saw palmetto, emphasizing the importance of scalp health and DHT reduction. The user shares personal experiences and suggests a balanced approach, combining topical treatments and lifestyle changes for effective hair regrowth.

community My hair journey as a 20+ year old with genetic hair loss and thoughts of pregnancy soon

in Female 1 upvotes 1 year ago

A 28-year-old woman with genetic hair loss has tried various treatments, including oral minoxidil, finasteride, dutasteride, vitamins, ketoconazole shampoo, exosome needling, and hair extensions. She plans to pause treatments for pregnancy and is concerned about potential hair loss during that time.

community I (diffuse thinner) would genuinely prefer having the Generic MPB hairloss

in Chat 35 upvotes 1 year ago

The conversation discusses struggles with diffuse thinning and hair loss treatments, including the use of dutasteride, minoxidil, and finasteride, with limited success. The original poster regrets having a hair transplant at 21 due to weak donor hair and ongoing thinning.

community 26 , hairloss general questions

in Is this regrowth? 14 upvotes 1 year ago

The user has been using finasteride, minoxidil, and Nizoral for hair loss but is not seeing much regrowth. Suggestions include trying oral minoxidil with dutasteride, and some users believe the hair looks better in recent pictures.

community How to recover from creatine hairloss?

10 upvotes 4 years ago

Creatine may accelerate hair loss in those genetically prone to male pattern baldness, but stopping its use can lead to hair regrowth. Treatments discussed include minoxidil, finasteride, tretinoin, derma rolling, and herbal remedies like saw palmetto.

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Learn

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learn Scalp Micropigmentation

Is scalp micropigmentation suitable for all types of hair loss? Scalp micropigmentation is generally suitable for various types of hair loss.

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Experts

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi