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GlossaryHairless Gene

gene regulating hair growth, mutations cause permanent hair loss

The Hairless Gene, often abbreviated as HR gene, is a gene that plays a crucial role in the regulation of hair growth and development. Mutations in this gene can lead to conditions such as congenital atrichia, where individuals are born with hair that is subsequently lost and not regrown, resulting in permanent hairlessness. This gene is essential for the normal cycling of hair follicles and the maintenance of hair.

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research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

139 citations, September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.

research A Distinct Gene Close to the Hairless Locus on Chromosome 8p Underlies Hereditary Marie Unna Type Hypotrichosis in a German Family

36 citations, October 2000 in “British Journal of Dermatology”

A different gene near the hairless gene on chromosome 8p21 causes a rare hair loss condition in a German family.

research Intragenic Deletion in the Desmoglein 4 Gene Underlies the Skin Phenotype in the Iffa Credo Hairless Rat

28 citations, October 2004 in “Differentiation”

A gene deletion causes the "hairless" trait in Iffa Credo rats.

research Atrichia With Papular Lesions Resulting From a Novel Insertion Mutation in the Human Hairless Gene

19 citations, May 2006 in “Clinical and Experimental Dermatology”

Researchers found a new mutation causing total hair loss from birth.

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

17 citations, May 2012 in “Journal of biological chemistry/The Journal of biological chemistry”

Hairless protein affects hair follicle structure by regulating the Dlx3 gene.

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community When did you know it was time to intervene in your hair loss? The truth hurts, but it’s good for someone to be up front with you

in Chat 54 upvotes 1 year ago

A person realized they were balding when their sister pointed it out and is now using a combination of hair loss treatments including finasteride, minoxidil, microneedling, and plans to add dutasteride and RU58841. Others in the conversation emphasize the importance of honesty about hair loss and caution against an overly aggressive treatment regimen, especially before a hair transplant.

community After 1.5 years+ on dut/fin hairless has finally slowed!

in Finasteride/Dutasteride 76 upvotes 3 years ago

After 1.5 years on finasteride and dutasteride with continued hair loss, the user noticed a significant reduction in hair shedding, attributing it to the consistent use of finasteride, along with a no-shampoo approach, multivitamins, vitamin D, and restarting minoxidil. Other users shared their happiness for the improvement and noted that hair loss can fluctuate naturally over time.

community Anyone else realize how many younger guys are balding?

in Chat 262 upvotes 1 month ago

Many younger men are experiencing hair loss due to genetics, diet, stress, and lifestyle changes. Treatments like finasteride and minoxidil are mentioned, with some users noting improvements.

community Testosterone in Reference Range Doesn't Cause Hair Loss

in Research/Science 51 upvotes 9 months ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community Dude had better hair at over 100 years of age than many of us at 20

in Satire 1456 upvotes 1 year ago

Hair loss discussion mentions Native Americans' resistance to male pattern baldness and lack of facial hair. Users discuss genetics, sun exposure, and potential treatments like minoxidil and finasteride.

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